Journal article
Early Detection of Huntington Disease
Future neurology, Vol.5(1), pp.85-104
01/2010
DOI: 10.2217/fnl.09.78
PMCID: PMC3860286
PMID: 24348095
Abstract
Huntington disease (HD) is a devastating illness, although its autosomal dominant genetic transmission allows a unique opportunity to study apparently healthy individuals before manifest disease. Attempts to study early disease are not unique in neurology (e.g., Mild Cognitive Impairment, Vascular Cognitive Impairment), but studying otherwise-healthy appearing individuals who will go on with nearly 99% certainty to manifest the symptoms of brain disease does provide distinct but valuable information about the true natural history of the disease. The field has witnessed an explosion of research examining possible early indicators of HD during what is now referred to as the “prodrome” of HD. A NIH study in its ninth year (PREDICT-HD) has offered a glimpse into the transition from an apparently healthy state to an obviously diseased state, and can serve as a model for many other genetic diseases, both neurological and non-neurological.
Details
- Title: Subtitle
- Early Detection of Huntington Disease
- Creators
- Jane S Paulsen - University of Iowa, The Roy J. and Lucille A. Carver College of Medicine, Departments of Psychiatry, Neurology, Neurosciences, and Psychology, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Future neurology, Vol.5(1), pp.85-104
- DOI
- 10.2217/fnl.09.78
- PMID
- 24348095
- PMCID
- PMC3860286
- NLM abbreviation
- Future Neurol
- ISSN
- 1479-6708
- eISSN
- 1748-6971
- Grant note
- R01 NS040068 || NS / National Institute of Neurological Disorders and Stroke : NINDS
- Language
- English
- Date published
- 01/2010
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083834002771
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