Journal article
Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women
Cancer epidemiology, biomarkers & prevention, Vol.25(7), pp.1151-1157
07/2016
DOI: 10.1158/1055-9965.EPI-16-0185
PMCID: PMC4930720
PMID: 27197299
Abstract
Emerging evidence suggests positive associations between serum anti-Müllerian hormone (AMH), a marker of ovarian function, and breast cancer risk. Body size at young ages may influence AMH levels, but few studies have examined this. Also, no studies have examined the relation of AMH levels with breast density, a strong predictor of breast cancer risk.
We examined associations of early life body fatness, AMH concentrations, and breast density among 172 women in the Dietary Intervention Study in Children (DISC). Height and weight were measured at baseline (ages 8-10) and throughout adolescence. Serum AMH concentrations and breast density were assessed at ages 25-29 at the DISC 2006 Follow-up visit. We used linear mixed effects models to quantify associations of AMH (dependent variable) with quartiles of age-specific youth body mass index (BMI) Z-scores (independent variable). We assessed cross-sectional associations of breast density (dependent variable) with AMH concentration (independent variable).
Neither early life BMI nor current adult BMI was associated with AMH concentrations. There were no associations between AMH and percent or absolute dense breast volume. In contrast, women with higher AMH concentrations had significantly lower absolute nondense breast volume (Ptrend < 0.01).
We found no evidence that current or early life BMI influences AMH concentrations in later life. Women with higher concentrations of AMH had similar percent and absolute dense breast volume, but lower nondense volume.
These results suggest that AMH may be associated with lower absolute nondense breast volume; however, future prospective studies are needed to establish temporality. Cancer Epidemiol Biomarkers Prev; 25(7); 1151-7. ©2016 AACR.
Details
- Title: Subtitle
- Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women
- Creators
- Kimberly A Bertrand - Slone Epidemiology Center at Boston University, Boston, Massachusetts. kab15@bu.eduHeather J Baer - Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MassachusettsE John Orav - Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MassachusettsCatherine Klifa - Dangeard Group, Aix-en-Provence, FranceAjay Kumar - Ansh Labs Inc., Webster, TexasNola M Hylton - Department of Radiology, University of California, San Francisco, CaliforniaErin S LeBlanc - Kaiser Permanente Center for Health Research, Portland, OregonLinda G Snetselaar - College of Public Health, University of Iowa, Iowa City, IowaLinda Van Horn - Department of Preventive Medicine, Northwestern University, Chicago, IllinoisJoanne F Dorgan - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.25(7), pp.1151-1157
- Publisher
- United States
- DOI
- 10.1158/1055-9965.EPI-16-0185
- PMID
- 27197299
- PMCID
- PMC4930720
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Grant note
- K01 HS019789 / AHRQ HHS R01 CA116182 / NCI NIH HHS P30 CA060553 / NCI NIH HHS R01 CA104670 / NCI NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 07/2016
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995121302771
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