Journal article
Early Prediction of Preeclampsia: Hope for Early Intervention?
Current women's health reviews, Vol.11(2), pp.120-126
01/01/2015
DOI: 10.2174/157340481102151218122020
Abstract
Preeclampsia is a hypertensive disorder of pregnancy that is diagnosed after the 20th week of gestation. It is defined by the American College of Obstetrics and Gynecology as de novo hypertension of at least 140/90 in a pregnant woman. Proteinuria with the hypertension is sufficient but not required for the diagnosis, especially if a woman displays severe symptoms such as headache, blurry vision, right upper quadrant pain, and low platelet count [1]. Despite significant research, preeclampsia continues to kill 76,000 mothers and 500,000 babies per year worldwide [2]. It causes short and long term consequences such as future metabolic and cardiovascular events for the mother and the child born during a pregnancy affected by preeclampsia [3-5]. A delay in diagnosis and delayed access to appropriate care is a core cause of the preeclampsia related morbidity and severe mortality worldwide. The complex pathogenesis of preeclampsia has challenged the ability to effectively predict preeclampsia to decrease the delay in this diagnosis. Consequently, early intervention or triage to higher level obstetric care is hindered. The lack of an early biomarker for preeclampsia also represents a major barrier to treat preeclampsia before major clinical symptoms emerge and the cycle of future cardiovascular risk for mom and baby begins. Novel, very early pregnancy predictive tests for preeclampsia may provide significant clinical utility. This review addresses current strong biomarkers of preeclampsia and their relevance to the prediction and the pathogenesis of preeclampsia.
Details
- Title: Subtitle
- Early Prediction of Preeclampsia: Hope for Early Intervention?
- Creators
- Mark Santillan - Univ Iowa, Carver Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, 200 Hawkins Dr, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Current women's health reviews, Vol.11(2), pp.120-126
- Publisher
- Bentham Science Publ Ltd
- DOI
- 10.2174/157340481102151218122020
- ISSN
- 1573-4048
- eISSN
- 1875-6581
- Number of pages
- 7
- Grant note
- Preeclampsia Foundation Swift Family Foundation University of Iowa Departments of Obstetrics and Gynecology and Pharmacology Shelly Bridgewater Dreams Foundation Roy J. Carver Charitable Trust 14 IRG 18710013; 15 SFRN 23860007; 15 SFRN 23730000; 15 SFRN 23760002 / American Heart Association National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Children's Miracle Network Reproductive Scientist Development Program HD000849; RR024980 / Iowa CTSA Scholar Program
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984318225002771
Metrics
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