Early adverse experience and substance addiction: dopamine, oxytocin, and glucocorticoid pathways

Sohye Kim; Stephanie Kwok; Linda C Mayes; Marc N Potenza; Helena J V Rutherford; Lane Strathearn

doi:10.1111/nyas.13140

Back

Early adverse experience and substance addiction: dopamine, oxytocin, and glucocorticoid pathways

Journal article

Open access

Peer reviewed

Early adverse experience and substance addiction: dopamine, oxytocin, and glucocorticoid pathways

Sohye Kim, Stephanie Kwok, Linda C Mayes, Marc N Potenza, Helena J V Rutherford and Lane Strathearn

Annals of the New York Academy of Sciences, Vol.1394(1), pp.74-91

04/2017

DOI: 10.1111/nyas.13140

PMCID: PMC5303188

PMID: 27508337

Files and links (1)

url

http://doi.org/10.1111/nyas.13140View

Open Access

Abstract

Substance addiction may follow a chronic, relapsing course and critically undermine the physical and psychological well-being of the affected individual and the social units of which the individual is a member. Despite the public health burden associated with substance addiction, treatment options remain suboptimal, with relapses often seen. The present review synthesizes growing insights from animal and human research to shed light upon developmental and neurobiological pathways that may increase susceptibility to addiction. We examine the dopamine system, the oxytocin system, and the glucocorticoid system, as they are particularly relevant to substance addiction. Our aim is to delineate how early adverse experience may induce long-lasting alterations in each of these systems at molecular, neuroendocrine, and behavioral levels and ultimately lead to heightened vulnerability to substance addiction. We further discuss how substance addiction in adulthood may increase the risk of suboptimal caregiving for the next generation, perpetuating the intergenerational cycle of early adverse experiences and addiction.

Signal Transduction

Substance-Related Disorders - metabolism

Animals

Glucocorticoids - metabolism

Humans

Substance-Related Disorders - psychology

Oxytocin - metabolism

Substance-Related Disorders - physiopathology

Dopamine - metabolism

Details

Title: Subtitle: Early adverse experience and substance addiction: dopamine, oxytocin, and glucocorticoid pathways
Creators: Sohye Kim - Attachment and Neurodevelopment Laboratory, Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas
Stephanie Kwok - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas
Linda C Mayes - Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut
Marc N Potenza - Connecticut Mental Health Center, New Haven, Connecticut
Helena J V Rutherford - Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut
Lane Strathearn - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Annals of the New York Academy of Sciences, Vol.1394(1), pp.74-91
DOI: 10.1111/nyas.13140
PMID: 27508337
PMCID: PMC5303188
NLM abbreviation: Ann N Y Acad Sci
ISSN: 0077-8923
eISSN: 1749-6632
Publisher: Wiley; United States
Grant note: R01 HD065819 / NICHD NIH HHS R03 HD080998 / NICHD NIH HHS R01 DA026437 / NIDA NIH HHS
Language: English
Date published: 04/2017
Academic Unit: Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Developmental and Behavioral Pediatrics; Neuroscience and Pharmacology
Record Identifier: 9984040340802771

Metrics

19 Record Views

59 Times Cited - Web of Science