Journal article
Early and Recent Exposure to Adversity, TLR-4 Stimulated Inflammation, and Diurnal Cortisol in Women with Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Research Network Study
Brain, behavior, and immunity, Vol.111, pp.116-123
07/2023
DOI: 10.1016/j.bbi.2023.03.024
PMCID: PMC10474614
PMID: 37001828
Abstract
Both early (ELA) and recent life adversity (RLA) have been linked with chronic pain conditions and persistent alterations of neuroendocrine and inflammatory responses. Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic urologic disorder characterized by bladder and/or pelvic pain, and excessive urinary frequency and/or urgency. IC/BPS has been associated with high levels of ELA as well as a distinct inflammatory signature. However, associations between ELA and RLA with inflammatory mechanisms in IC/BPS that might underlie the link between adversity and symptoms have not been examined. Here we investigated ELA and RLA in women with IC/BPS as potential risk factors for inflammatory processes and hypothalamic-pituitary-adrenal (HPA) abnormalities using data from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Women with IC/BPS and healthy controls (n=154 and 32, respectively) completed surveys, collected salivary cortisol at awakening and bedtime for 3 days, and gave a blood sample which was analyzed for 7 LPS-stimulated cytokines and chemokines (IL-6, TNFα, IL-1β, MIP1α, MCP1, IL-8, and IL-10). Two cytokine/chemokine composites were identified using principal components analysis. Patients with greater exposure to RLA or cumulative ELA and RLA of at least moderate severity showed elevated levels of a composite of all cytokines, adjusting for age, body mass index, and study site. Furthermore, there was a trending relationship between ELA and the pro-inflammatory composite score. Nocturnal cortisol and cortisol slope were not associated with ELA, RLA, or inflammation. The present findings support the importance of adverse events in IC/BPS via a biological mechanism and suggest that ELA and RLA should be assessed as risk factors for inflammation as part of a clinical workup for IC/BPS.
Details
- Title: Subtitle
- Early and Recent Exposure to Adversity, TLR-4 Stimulated Inflammation, and Diurnal Cortisol in Women with Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Research Network Study
- Creators
- Susan K LutgendorfSharaf Zia - Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA, USAYi Luo - University of IowaMichael O'Donnell - University of IowaAdrie van Bokhoven - University of Colorado Anschutz Medical CampusCatherine S Bradley - University of IowaRobert Gallup - West Chester UniversityJennifer Pierce - University of MichiganBayley J Taple - Northwestern UniversityBruce D Naliboff - University of California, Los AngelesJ Quentin Clemens - University of MichiganKarl J Kreder - University of IowaAndrew Schrepf - University of Michigan
- Resource Type
- Journal article
- Publication Details
- Brain, behavior, and immunity, Vol.111, pp.116-123
- DOI
- 10.1016/j.bbi.2023.03.024
- PMID
- 37001828
- PMCID
- PMC10474614
- NLM abbreviation
- Brain Behav Immun
- ISSN
- 0889-1591
- eISSN
- 1090-2139
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: DK082315, DK082316, DK082325, DK082333, DK082342, DK082344, DK082345, DK082370, DK103227, DK103260, DK103271; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases
- Language
- English
- Electronic publication date
- 03/29/2023
- Date published
- 07/2023
- Academic Unit
- Epidemiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Writers’ Workshop; Urology
- Record Identifier
- 9984381136002771
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