Journal article
Early and late basilar artery thrombectomy time window outcomes
Frontiers in neurology, Vol.15, 1352310
01/26/2024
DOI: 10.3389/fneur.2024.1352310
PMCID: PMC10858612
PMID: 38343711
Abstract
Importance Stroke-to-recanalization time is a strong predictor of outcomes in anterior circulation large-vessel occlusion (LVO). The authors aimed to evaluate functional outcomes in early (<6 h) vs. late (6–24 h) time windows for thrombectomy-treated basilar artery occlusions. Methods Patients were derived from the Posterior Circulation Ischemic Stroke Evaluation: Analyzing Radiographic and Intra-procedural Predictors of Mechanical Thrombectomy (PC-SEARCH) Registry and retrospectively analyzed early and late basilar artery thrombectomy time windows cohorts. Patients were dichotomized based on the last known well and correlated to 90-day functional outcomes (mRS 0–3). A multiple logistic regression analysis was performed. Results A total of 405 patients were included in this study: 216 and 189 patients in the early and late time windows, respectively. Baseline demographic, stroke, radiographic, and intraprocedural characteristics were similar between the groups. A total of 99 (46%) and 79 (42%) patients in the early and late time windows, respectively, achieved favorable functional outcomes at 90 days ( p = 0.41), and multiple logistic regression analysis did not reveal differences between cohorts (OR: 0.74; 95% CI: 0.46–1.19; p = 0.22). Symptomatic hemorrhage (7% vs. 5%; p = 0.69) and neurological complications (8% vs. 9%; p = 0.83) were similar between the groups; however, hospital complications were more common in the early time window cohort (22% vs. 13%; p = 0.01). Conclusion The early and late thrombectomy time windows can achieve similar rates of 90-day favorable functional outcomes. However, timely thrombectomy influences the likelihood of achieving excellent functional outcomes (mRS ≤ 2) within the early time window.
Details
- Title: Subtitle
- Early and late basilar artery thrombectomy time window outcomes
- Creators
- Adam T. Mierzwa - University of ToledoRahul Rao - University of ToledoSami Al Kasab - Medical University of South CarolinaAshley Nelson - Medical University of South CarolinaSantiago Ortega-GutierrezJuan Vivanco-SuarezMudassir Farooqui - University of IowaAshutosh P. Jadhav - Barrow Neurological InstituteShashvat Desai - Barrow Neurological InstituteGabor Toth - Cleveland ClinicAnas Alrohimi - Cleveland ClinicThanh N. Nguyen - Boston UniversityPiers Klein - Boston UniversityMohamad Abdalkader - Boston UniversityHisham Salahuddin - Antelope Valley HospitalAditya Pandey - University of MichiganZachary Wilseck - University of MichiganSravanthi Koduri - University of MichiganNirav Vora - Riverside Methodist HospitalNameer Aladamat - University of ToledoKhaled Gharaibeh - University of ToledoEhad Afreen - University of ToledoSyed Zaidi - University of ToledoMouhammad Jumaa - University of Toledo
- Resource Type
- Journal article
- Publication Details
- Frontiers in neurology, Vol.15, 1352310
- DOI
- 10.3389/fneur.2024.1352310
- PMID
- 38343711
- PMCID
- PMC10858612
- NLM abbreviation
- Front Neurol
- ISSN
- 1664-2295
- eISSN
- 1664-2295
- Language
- English
- Date published
- 01/26/2024
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984554826202771
Metrics
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