Journal article
Early atrophy of pallidum and accumbens nucleus in Huntington’s disease
Journal of neurology, Vol.258(3), pp.412-420
03/2011
DOI: 10.1007/s00415-010-5768-0
PMCID: PMC3112014
PMID: 20936300
Abstract
In Huntington’s disease (HD) atrophy of the caudate nucleus and putamen has been described many years before clinical manifestation. Volume changes of the pallidum, thalamus, brainstem, accumbens nucleus, hippocampus, and amygdala are less well investigated, or reported with contradicting results. The aim of our study is to provide a more precise view of the specific atrophy of the subcortical grey matter structures in different stages of Huntington’s disease, and secondly to investigate how this influences the clinical manifestations. All TRACK-HD subjects underwent standardised T1-weighted 3T MRI scans encompassing 123 manifest HD (stage 1,
n
= 77; stage 2,
n
= 46), 120 premanifest HD (close to onset
n
= 58, far from onset
n
= 62) and 123 controls. Using FMRIB’s FIRST and SIENAX tools the accumbens nucleus, amygdala, brainstem, caudate nucleus, hippocampus, pallidum, putamen, thalamus and whole brain volume were extracted. Results showed that volumes of the caudate nucleus and putamen were reduced in premanifest HD far from predicted onset (>10.8 years). Atrophy of accumbens nucleus and pallidum was apparent in premanifest HD in the close to onset group (0–10.8 years). All other structures were affected to some degree in the manifest group, although brainstem, thalamus and amygdala were relatively spared. The accumbens nucleus, putamen, pallidum and hippocampus had a strong significant correlation with functional and motor scores. We conclude that volume changes may be a sensitive and reliable measure for early disease detection and in this way serve as a biomarker for Huntington’s disease. Besides the caudate nucleus and putamen, the pallidum and the accumbens nucleus show great potential in this respect.
Details
- Title: Subtitle
- Early atrophy of pallidum and accumbens nucleus in Huntington’s disease
- Creators
- Simon J. A van den Bogaard - Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The NetherlandsEve M Dumas - Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The NetherlandsTanka P Acharya - Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA USAHans Johnson - Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA USADouglas R Langbehn - Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA USARachael I Scahill - UCL Institute of Neurology, University College London, Queen Square, London, UKSarah J Tabrizi - UCL Institute of Neurology, University College London, Queen Square, London, UKMark A van Buchem - Department of Radiology, Leiden University Medical Center, Leiden, The NetherlandsJeroen van der Grond - Department of Radiology, Leiden University Medical Center, Leiden, The NetherlandsRaymund A. C Roos - Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The NetherlandsTRACK-HD Investigator Group
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, Vol.258(3), pp.412-420
- DOI
- 10.1007/s00415-010-5768-0
- PMID
- 20936300
- PMCID
- PMC3112014
- NLM abbreviation
- J Neurol
- ISSN
- 0340-5354
- eISSN
- 1432-1459
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- Language
- English
- Date published
- 03/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003908902771
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