Journal article
Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis
Neurobiology of disease, Vol.40(3), pp.531-543
12/2010
DOI: 10.1016/j.nbd.2010.07.013
PMCID: PMC2955781
PMID: 20682340
Abstract
Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. Therefore we hypothesized that hypothalamic changes occur already prior to the clinical diagnosis. We performed voxel-based morphometry and logistic regression analyses of cross-sectional MR images from 220 HD gene carriers and 75 controls in the Predict-HD study. We show that changes in the hypothalamic region are detectable before clinical diagnosis and that its grey matter contents alone are sufficient to distinguish HD gene carriers from control cases. In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI.
► Changes occur in the hypothalamic region in prodromal HD using MRI analysis. ► Grey matter alterations are detectable over a decade before motor symptoms in HD. ► Alterations in the hypothalamus parallel changes in the caudate and the insula. ► Mathematical models show high classification power of the hypothalamus in HD
Details
- Title: Subtitle
- Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis
- Creators
- Charlotte Soneson - Centre for Mathematical Sciences, Lund University, SwedenMagnus Fontes - Centre for Mathematical Sciences, Lund University, SwedenYongxia Zhou - Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, BMC D11, Lund University, SwedenVladimir Denisov - Lund University Bioimaging Center, Lund University, SwedenJane S Paulsen - Department of Psychiatry, The University of Iowa, USADeniz Kirik - Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, BMC D11, Lund University, SwedenÅsa Petersén - Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, BMC D11, Lund University, SwedenPREDICT-HD Investigators of the Huntington Study Group
- Resource Type
- Journal article
- Publication Details
- Neurobiology of disease, Vol.40(3), pp.531-543
- DOI
- 10.1016/j.nbd.2010.07.013
- PMID
- 20682340
- PMCID
- PMC2955781
- NLM abbreviation
- Neurobiol Dis
- ISSN
- 0969-9961
- eISSN
- 1095-953X
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/501100004359, name: Swedish Research Council, award: M2006-6238, K2009-61X-21520-01-1, K2009-61P-20945-03-1; name: Torsten och Ragnar Soderberg Foundation; name: Bagadilico network; DOI: 10.13039/501100003173, name: Crafoord Foundation; name: Jeanssons Foundations; name: The Swedish National Board of Health and Welfare; DOI: 10.13039/100007435, name: Åke Wiberg Foundation; name: province of Skane state grants; name: NeuroFortis; DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke, award: 40068; DOI: 10.13039/100000025, name: National Institutes of Mental Health, award: 01579; name: Roy J. and Lucille Carver Trust; DOI: 10.13039/100000011, name: Howard Hughes Medical Institute; DOI: 10.13039/100000887, name: Huntington Disease Society of America; DOI: 10.13039/100005725, name: CHDI Foundation, Inc.
- Language
- English
- Date published
- 12/2010
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984003915702771
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