Journal article
Early emphysematous changes in asymptomatic smokers : Detection with 3He MR imaging
Radiology, Vol.239(3), pp.875-883
2006
DOI: 10.1148/radiol.2393050111
PMID: 16714465
Abstract
Purpose: To prospectively compare apparent diffusion coefficient (ADC) measurements derived from diffusion-weighted hyperpolarized helium 3 (3He) magnetic resonance (MR) imaging with functional and structural findings using spirometric tests and thin-section computed tomography (CT) of the lungs in asymptomatic smokers and healthy nonsmokers of similar age.
Materials and Methods: All studies were HIPAA compliant and were approved by the institutional review board. Informed consent was obtained. Ventilation and diffusion-weighted 3He MR images were obtained in healthy subjects: 11 smokers (five women, six men; mean age, 47 years ± 18 [standard deviation]; range, 23–73 years) and eight nonsmokers (<100 cigarettes in lifetime) (four women, four men; mean age, 46 years ± 16; range, 23–69 years). Mean ADC values for smokers and nonsmokers were compared with spirometric values, diffusing capacity of the lung for carbon monoxide (DLCO), age, and pack-years with Spearman rank correlation coefficient (rs) and multiple linear regression analysis. Mean ADC value and thin-section CT emphysema index of relative area less than −950 HU (RA950) were compared on a regional basis by using linear mixed-effect models.
Results: Mean ADC values and number of pack-years were significantly correlated (rs = 0.60; 95% confidence interval (CI): 0.21, 1.00; P = .007); relationship remained significant after adjustment for age (P = .003). DLCO was strongly correlated with pack-years (rs = −0.63; 95% CI: −0.97, −0.29; P = .004). Negative correlations between mean ADC values and percentage predicted DLCO (rs = −0.79; 95% CI: −0.93, −0.64; P < .001) and the ratio of forced expiratory volume in 1 second to forced vital capacity (rs = −0.72; 95% CI: −0.92, −0.52; P = .001) were statistically significant. Correlations between spirometric values or RA950 and number of pack-years were not significant (.05 level).
Conclusion: Correlations between mean ADC values and pulmonary function test measurements for diagnosing emphysema, especially DLCO, were statistically significant.
Details
- Title: Subtitle
- Early emphysematous changes in asymptomatic smokers : Detection with 3He MR imaging
- Creators
- Sean B Fain - University of Wisconsin–MadisonShilpa R Panth - University of Wisconsin–MadisonMichael D Evans - University of Wisconsin–MadisonAndrew L Wentland - University of Wisconsin–MadisonJames H Holmes - University of Wisconsin–MadisonFrank R Korosec - University of Wisconsin–MadisonMatthew J O'Brien - University of Wisconsin–MadisonHarvey FountaineThomas M Grist - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.239(3), pp.875-883
- DOI
- 10.1148/radiol.2393050111
- PMID
- 16714465
- NLM abbreviation
- Radiology
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Publisher
- Radiological Society of North America
- Language
- English
- Date published
- 2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Stead Family Department of Pediatrics; Psychological and Quantitative Foundations; Health, Sport, and Human Physiology
- Record Identifier
- 9984275053302771
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