Journal article
Early mortality and overall survival in acute promyelocytic leukemia: do real-world data match results of the clinical trials?
Leukemia & lymphoma, Vol.62(8), pp.1949-1957
07/03/2021
DOI: 10.1080/10428194.2021.1894651
PMCID: PMC9429085
PMID: 33711907
Abstract
Acute promyelocytic leukemia (APL) boasts overall survival (OS) of >90% at 3 years and early mortality of <5% in recent clinical trials. Using a large National Cancer Database, we performed analysis of 7190 adults with APL to determine whether one-month mortality and OS of patients with APL treated in real-world practices mirror outcomes noted in clinical trials. Only 64% of total patients received multi-agent therapy; 32% received either single-agent therapy or no therapy at all. One-month mortality was 6% for patients ≤18 years, 6% for 19-40 years, 10% for 41-60 years, and 21% for >60 years. OS at 1- and 3-year were 81% and 75%, respectively. In a multivariate analysis, age ≤ 40 years, treatment at academic center, use of multi-agent therapy, and diagnosis after 2009 conferred better OS. In this largest database study in APL till date, we demonstrated an overall improvement in OS over time but challenges still exist in translating successes of clinical trials to real-world practices.
Details
- Title: Subtitle
- Early mortality and overall survival in acute promyelocytic leukemia: do real-world data match results of the clinical trials?
- Creators
- Prajwal Dhakal - University of Iowa, Internal MedicineElizabeth Lyden - Department of Biostatics, University of Nebraska Medical CenterVenkat Rajasurya - Department of Pulmonary Critical Care, Multicare Health SystemAmer M Zeidan - Department of Internal Medicine, Section of Hematology, Yale University School of Medicine and Yale Cancer CenterChakra Chaulagain - Department of Hematology and Oncology, Maroone Cancer Center, Cleveland Clinic FloridaKrishna Gundabolu - Fred and Pamela Buffett Cancer Center, University of Nebraska Medical CenterVijaya Raj Bhatt - Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Leukemia & lymphoma, Vol.62(8), pp.1949-1957
- DOI
- 10.1080/10428194.2021.1894651
- PMID
- 33711907
- PMCID
- PMC9429085
- NLM abbreviation
- Leuk Lymphoma
- ISSN
- 1042-8194
- eISSN
- 1029-2403
- Publisher
- Taylor & Francis
- Grant note
- DOI: 10.13039/100000057, name: National Institute of General Medical Sciences, award: 1 U54 GM115458; name: Great Plains Institutional Development Award; name: Clinical Translational Research (CTR) Network
- Language
- English
- Date published
- 07/03/2021
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984119798202771
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