Early neurobehavioral deficits as phenotypic indicators of the schizophrenia genotype and predictors of later psychosis

Robert A. Philibert; Harinder K. Sandhu; Ana M. Hutton; Zhewu Wang; Stephan Arndt; Nancy C. Andreasen; Raymond Crowe; Thomas H. Wassink

doi:10.1002/1096-8628(20010108)105:1<23::AID-AJMG1048>3.0.CO;2-0

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Early neurobehavioral deficits as phenotypic indicators of the schizophrenia genotype and predictors of later psychosis

Journal article

Peer reviewed

Early neurobehavioral deficits as phenotypic indicators of the schizophrenia genotype and predictors of later psychosis

Robert A. Philibert, Harinder K. Sandhu, Ana M. Hutton, Zhewu Wang, Stephan Arndt, Nancy C. Andreasen, Raymond Crowe and Thomas H. Wassink

American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.105(1), pp.23-24

01/08/2001

DOI: 10.1002/1096-8628(20010108)105:1<23::AID-AJMG1048>3.0.CO;2-0

PMID: 11424986

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Abstract

Schizophrenia is a genetically complex disorder that requires sharper delineation of its phenotypic boundaries. Considerable attention has been devoted in recent family and high-risk studies to the identification of both subclinical and other phenotypes, such as neurobehavioral deficits, that may be indicators of the genetic liability to schizophrenia. In high-risk studies, candidate liability indicators that are evident by young ages are also evaluated for their ability to predict future schizophrenia or spectrum disorders. We report on assessments of verbal short-term memory, gross motor skills, and global attention administered in midchildhood to offspring of schizophrenic, affectively ill, and normal parents as predictors of adult psychoses and as possible indicators of schizophrenia-susceptibility genes.

Schizophrenia

Genetic liability indicators

Neurobehavioral deficits

Prediction of psychosis

Details

Title: Subtitle: Early neurobehavioral deficits as phenotypic indicators of the schizophrenia genotype and predictors of later psychosis
Creators: Robert A. Philibert - Neuroscience Program, University of Iowa, Psychiatry Research, MEB, United States
Harinder K. Sandhu - Department of Psychiatry, University of Iowa, United States
Ana M. Hutton - University of Iowa
Zhewu Wang - Department of Psychiatry, University of Iowa, United States
Stephan Arndt - Department of Psychiatry, University of Iowa, United States
Nancy C. Andreasen - University of Iowa
Raymond Crowe - University of Iowa
Thomas H. Wassink - University of Iowa
Resource Type: Journal article
Publication Details: American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.105(1), pp.23-24
DOI: 10.1002/1096-8628(20010108)105:1<23::AID-AJMG1048>3.0.CO;2-0
PMID: 11424986
ISSN: 1552-4841
eISSN: 1552-485X
Number of pages: 2
Language: English
Date published: 01/08/2001
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Nursing; Injury Prevention Research Center
Record Identifier: 9985132191802771

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