Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes

Benjamin R Campbell; Courtney B Sanders; James L Netterville; Robert J Sinard; Sarah L Rohde; Alexander Langerman; Kyle Mannion; Young J Kim; Barbara A Murphy; James S Lewis Jr; Jeremy L Warner; Derek K Smith; Krystle A Lang Kuhs

doi:10.1002/hed.25650

Back

Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes

Journal article

Peer reviewed

Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes

Benjamin R Campbell, Courtney B Sanders, James L Netterville, Robert J Sinard, Sarah L Rohde, Alexander Langerman, Kyle Mannion, Young J Kim, Barbara A Murphy, James S Lewis Jr, …

Head & neck, Vol.41(6), pp.1952-1960

06/2019

DOI: 10.1002/hed.25650

PMCID: PMC7010313

PMID: 30633435

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/7010313View

Open Access

Abstract

Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2-6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8-15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2-0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.

Tobacco

oral tongue

snuff

young

squamous cell carcinoma

Details

Title: Subtitle: Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes
Creators: Benjamin R Campbell - Vanderbilt University
Courtney B Sanders - Vanderbilt University
James L Netterville - Vanderbilt University Medical Center
Robert J Sinard - Vanderbilt University Medical Center
Sarah L Rohde - Vanderbilt University Medical Center
Alexander Langerman - Vanderbilt University Medical Center
Kyle Mannion - Vanderbilt University Medical Center
Young J Kim - Vanderbilt University Medical Center
Barbara A Murphy - Vanderbilt University Medical Center
James S Lewis Jr - Vanderbilt University Medical Center
Jeremy L Warner - Vanderbilt University Medical Center
Derek K Smith - Vanderbilt University Medical Center
Krystle A Lang Kuhs - Vanderbilt University Medical Center
Resource Type: Journal article
Publication Details: Head & neck, Vol.41(6), pp.1952-1960
DOI: 10.1002/hed.25650
PMID: 30633435
PMCID: PMC7010313
NLM abbreviation: Head Neck
ISSN: 1043-3074
eISSN: 1097-0347
Grant note: UL1 TR000445 from NCATS/NIH / Vanderbilt Institute for Clinical and Translational Research Vanderbilt University Medical Center UL1 TR000445 / NCATS NIH HHS K07 CA218247 / NCI NIH HHS Vanderbilt University Medical Center institutional funding
Language: English
Date published: 06/2019
Academic Unit: Preventive and Community Dentistry; Dental Research
Record Identifier: 9984966752902771

Metrics

4 Record Views

See more details