Journal article
Early recovery after cerebral ischemia risk of subsequent neurological deterioration
Annals of neurology, Vol.54(4), pp.439-444
2003
DOI: 10.1002/ana.10678
PMID: 14520654
Abstract
Given the high short-term risk of stroke after transient ischemic attack, we hypothesized that substantial acute neurological recovery in patients presenting with cerebral ischemia would be associated with a greater risk of subsequent neurological deterioration due to recurrent cerebral ischemia. Data from the Trial of ORG10172 in Acute Stroke Treatment, a randomized trial of the heparinoid danaparoid, were analyzed to determine whether substantial acute recovery, defined as an improvement of greater than or equal to 75% on National Institutes of Health Stroke Scale (NIHSS) between baseline and 24 hours, was associated with a greater risk of subsequent deterioration, defined as a worsening on the NIHSS between day 1 and day 90. Of 1,184 subjects meeting entry criteria, 63 (5.3%) had substantial acute recovery. Subsequent deterioration was more common in those with substantial acute recovery compared with others (48 vs 33%; p = 0.028 by Fisher's exact test). In multivariable models, substantial acute recovery remained an independent predictor of subsequent deterioration (odds ratio, 3.0; 95% confidence interval, 1.7-5.2; p < 0.001). Among patients with acute cerebral ischemia, those who recover substantially within 24 hours may be at greater risk of subsequent neurological deterioration due to causes other than hemorrhage.
Details
- Title: Subtitle
- Early recovery after cerebral ischemia risk of subsequent neurological deterioration
- Creators
- S. Claiborne JOHNSTON - Department of Neurology, University of California, San Francisco, CA, United StatesEnrique C LEIRA - Souers Stroke Institute, Department of Neurology, St. Louis University, St. Louis, MO, United StatesMichael D HANSEN - Department of Biostatistics, University of Iowa, IA, United StatesHarold P ADAMS - Department of Neurology, University of Iowa, IA, United States
- Resource Type
- Journal article
- Publication Details
- Annals of neurology, Vol.54(4), pp.439-444
- Publisher
- Willey-Liss; Hoboken
- DOI
- 10.1002/ana.10678
- PMID
- 14520654
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- Language
- English
- Date published
- 2003
- Academic Unit
- Neurology; Epidemiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020857702771
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