Early versus late repair of rotator cuff tears in rats

Leonardo Cavinatto; Eduardo Angeli Malavolta; Cesar Augusto Martins Pereira; Manuela Miranda-Rodrigues; Luiza Campos Moreira Silva; Cecilia Helena Gouveia; Cesar de Cesar Netto; Rames Mattar Junior; Arnaldo Amado Fereira Neto

doi:10.1016/j.jse.2017.10.025

Back

Early versus late repair of rotator cuff tears in rats

Journal article

Open access

Peer reviewed

Early versus late repair of rotator cuff tears in rats

Leonardo Cavinatto, Eduardo Angeli Malavolta, Cesar Augusto Martins Pereira, Manuela Miranda-Rodrigues, Luiza Campos Moreira Silva, Cecilia Helena Gouveia, Cesar de Cesar Netto, Rames Mattar Junior and Arnaldo Amado Fereira Neto

Journal of shoulder and elbow surgery, Vol.27(4), pp.606-613

04/2018

DOI: 10.1016/j.jse.2017.10.025

PMID: 29274903

Files and links (1)

url

http://dx.doi.org/10.1016/j.jse.2017.10.025View

Open Access

Abstract

In the event of a traumatic rotator cuff tear, patients are routinely advised that early surgical intervention produces an optimal repair, despite a lack of direct evidence to support this recommendation. To address this knowledge gap, massive rotator cuff tears in rats were assessed by biomechanical and bone morphometric analyses after early or late repair. Combined supraspinatus and infraspinatus tendon tears of the left shoulder were created in 21 adult Wistar rats, which were divided into 2 groups. The tendons of the injured shoulder in the animals in group I were surgically repaired 8 weeks after the injury. Under the same anesthesia, the same injury was created on the right shoulder, which was immediately repaired. The rats from group I were euthanized 8 weeks after the repairs. No repair was performed in the rats from group II, which were euthanized 8 weeks after the injury. Tissues from both groups were harvested and biomechanically tested for supraspinatus tendon and bone morphometry analysis of the humeral head. All biomechanical properties were significantly increased in the early repair group compared with the late repair group. No significant differences were observed in bone morphometry of the humeral head when early and late repair groups were compared. Early surgical repair of a massive rotator cuff tear leads to improved biomechanical properties of the tissue after healing. Proximal humerus bone morphometry was unaffected by surgical repair timing.

animal models

biomechanics

rats

rotator cuff

Shoulder

X-ray microtomography

Details

Title: Subtitle: Early versus late repair of rotator cuff tears in rats
Creators: Leonardo Cavinatto - Institute of Orthopaedics and Traumatology, University of Sao Paulo, São Paulo, SP, Brazil
Eduardo Angeli Malavolta - Institute of Orthopaedics and Traumatology, University of Sao Paulo, São Paulo, SP, Brazil
Cesar Augusto Martins Pereira - Institute of Orthopaedics and Traumatology, University of Sao Paulo, São Paulo, SP, Brazil
Manuela Miranda-Rodrigues - Institute of Biomedical Sciences, Department of Anatomy, University of Sao Paulo, São Paulo, SP, Brazil
Luiza Campos Moreira Silva - Institute of Orthopaedics and Traumatology, University of Sao Paulo, São Paulo, SP, Brazil
Cecilia Helena Gouveia - Institute of Biomedical Sciences, Department of Anatomy, University of Sao Paulo, São Paulo, SP, Brazil
Cesar de Cesar Netto - Institute of Orthopaedics and Traumatology, University of Sao Paulo, São Paulo, SP, Brazil
Rames Mattar Junior - Institute of Orthopaedics and Traumatology, University of Sao Paulo, São Paulo, SP, Brazil
Arnaldo Amado Fereira Neto - Institute of Orthopaedics and Traumatology, University of Sao Paulo, São Paulo, SP, Brazil
Resource Type: Journal article
Publication Details: Journal of shoulder and elbow surgery, Vol.27(4), pp.606-613
DOI: 10.1016/j.jse.2017.10.025
PMID: 29274903
NLM abbreviation: J Shoulder Elbow Surg
ISSN: 1058-2746
eISSN: 1532-6500
Publisher: Elsevier Inc
Language: English
Date published: 04/2018
Academic Unit: Orthopedics and Rehabilitation
Record Identifier: 9984040240202771

Metrics

31 Record Views

15 Times Cited - Web of Science