Journal article
Eaton-Lambert Syndrome: Ultrastructural Study of the Motor End-Plates
Archives of neurology (Chicago), Vol.27(1), pp.67-78
07/01/1972
DOI: 10.1001/archneur.1972.00490130069009
PMID: 5049681
Abstract
Sixty-three motor end-plates of the biopsied muscle fibers from four patients with Eaton-Lambert myasthenic syndrome were studied. Ultrastructural findings were characterized by (1) demyelination and remyelination of the preterminal intramuscular nerves; (2) degeneration and atrophy of the terminal axons; (3) widened junctional plates; (4) numerous elongated, widened, and irregularly ramified secondary synaptic clefts with vesicles subjacent to the postsynaptic membrane; and (5) "megaconial" mitochondria in the muscle fibers. The characteristic changes of the secondary synaptic clefts in Eaton-Lambert syndrome are thought to have resulted from repeated degeneration and regeneration of the terminal axons.
Details
- Title: Subtitle
- Eaton-Lambert Syndrome: Ultrastructural Study of the Motor End-Plates
- Creators
- Nobuyoshi FukuharaMasaharu TakamoriLudwig GutmannShi-Ming Chou
- Resource Type
- Journal article
- Publication Details
- Archives of neurology (Chicago), Vol.27(1), pp.67-78
- DOI
- 10.1001/archneur.1972.00490130069009
- PMID
- 5049681
- NLM abbreviation
- Arch Neurol
- ISSN
- 0003-9942
- eISSN
- 1538-3687
- Publisher
- American Medical Association
- Language
- English
- Date published
- 07/01/1972
- Academic Unit
- Neurology
- Record Identifier
- 9984020760002771
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