Echinacea in infection

Diane F Birt; Mark P Widrlechner; Carlie A Lalone; Lankun Wu; Jaehoon Bae; Avery Ks Solco; George A Kraus; Patricia A Murphy; Eve S Wurtele; Qiang Leng; Steven C Hebert; Wendy J Maury; Jason P Price

doi:10.1093/ajcn/87.2.488S

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Echinacea in infection

Diane F Birt, Mark P Widrlechner, Carlie A Lalone, Lankun Wu, Jaehoon Bae, Avery Ks Solco, George A Kraus, Patricia A Murphy, Eve S Wurtele, Qiang Leng, …

The American journal of clinical nutrition, Vol.87(2), pp.488S-492S

02/2008

DOI: 10.1093/ajcn/87.2.488S

PMCID: PMC2262947

PMID: 18258644

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Abstract

Ongoing studies have developed strategies for identifying key bioactive compounds and chemical profiles in Echinacea with the goal of improving its human health benefits. Antiviral and antiinflammatory-antipain assays have targeted various classes of chemicals responsible for these activities. Analysis of polar fractions of E. purpurea extracts showed the presence of antiviral activity, with evidence suggesting that polyphenolic compounds other than the known HIV inhibitor, cichoric acid, may be involved. Antiinflammatory activity differed by species, with E. sanguinea having the greatest activity and E. angustifolia, E. pallida, and E. simulata having somewhat less. Fractionation and studies with pure compounds indicate that this activity is explained, at least in part, by the alkamide constituents. Ethanol extracts from Echinacea roots had potent activity as novel agonists of TRPV1, a mammalian pain receptor reported as an integrator of inflammatory pain and hyperalgesia and a prime therapeutic target for analgesic and antiinflammatory drugs. One fraction from E. purpurea ethanol extract was bioactive in this system. Interestingly, the antiinflammatory compounds identified to inhibit prostaglandin E(2) production differed from those involved in TRPV1 receptor activation.

Anti-HIV Agents - pharmacology

Antiviral Agents - pharmacology

Anti-Inflammatory Agents - pharmacology

Nonprescription Drugs - pharmacology

Humans

TRPV Cation Channels - agonists

Analgesics, Non-Narcotic - pharmacology

Animals

Plant Roots

Polyphenols

Flavonoids - pharmacology

Echinacea

Phytotherapy

Plants, Medicinal

Phenols - pharmacology

Details

Title: Subtitle: Echinacea in infection
Creators: Diane F Birt - The Center for Research on Botanical Dietary Supplements, Iowa State University, Ames, IA 50011, USA. dbirt@iastate.edu
Mark P Widrlechner
Carlie A Lalone
Lankun Wu
Jaehoon Bae
Avery Ks Solco
George A Kraus
Patricia A Murphy
Eve S Wurtele
Qiang Leng
Steven C Hebert
Wendy J Maury
Jason P Price
Resource Type: Journal article
Publication Details: The American journal of clinical nutrition, Vol.87(2), pp.488S-492S
DOI: 10.1093/ajcn/87.2.488S
PMID: 18258644
PMCID: PMC2262947
ISSN: 0002-9165
eISSN: 1938-3207
Grant note: P01 ES012020-05 / NIEHS NIH HHS 95P50AT004155 / NCCIH NIH HHS P50 AT004155 / NCCIH NIH HHS P01 ES012020 / NIEHS NIH HHS
Language: English
Date published: 02/2008
Academic Unit: Microbiology and Immunology
Record Identifier: 9984083892202771

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