Echocardiographic predictors of adverse outcomes in infants with congenital diaphragmatic hernia

Joseph Y Ting; Arvind Sehgal; Mimi T Y Kuan; Amuchou Soraisham; Erika Vorhies; Michael Castaldo; Patrick J McNamara

doi:10.1038/s41372-026-02670-5

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Echocardiographic predictors of adverse outcomes in infants with congenital diaphragmatic hernia

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Echocardiographic predictors of adverse outcomes in infants with congenital diaphragmatic hernia

Joseph Y Ting, Arvind Sehgal, Mimi T Y Kuan, Amuchou Soraisham, Erika Vorhies, Michael Castaldo and Patrick J McNamara

Journal of perinatology

04/14/2026

DOI: 10.1038/s41372-026-02670-5

PMID: 41981122

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Abstract

To determine the relationship between echocardiography indices of heart function and adverse short-term outcomes in infants with congenital diaphragmatic hernia (CDH). This was a retrospective cohort study of infants with CDH from four neonatal surgical centres between 2018 and 2021. Serial targeted neonatal echocardiography was performed to assess myocardial function. The composite primary outcome was death or invasive mechanical ventilation beyond postnatal day 14. We identified 44 infants, and 18 (40.9%) met the composite primary outcome. They had lower pre-operative left ventricular output (110 vs. 157 mL/kg/min, p = 0.002), right ventricular output (114 vs. 187 mL/kg/min, p = 0.008), and peak systolic myocardial velocities measured at the mitral annulus (4.6 vs. 5.4 cm/s, p = 0.006) and interventricular septum (4.2 vs. 4.8 cm/s, p = 0.001). They exhibited lower post-operative right ventricular output (155 vs. 237 mL/kg/min, p = 0.021) and lower myocardial velocities on tissue Doppler imaging. Echocardiographic assessments may provide critical prognostic information regarding post-operative respiratory trajectories.

Details

Title: Subtitle: Echocardiographic predictors of adverse outcomes in infants with congenital diaphragmatic hernia
Creators: Joseph Y Ting - University of British Columbia
Arvind Sehgal - Monash Children’s Hospital
Mimi T Y Kuan - University of British Columbia
Amuchou Soraisham - University of Calgary
Erika Vorhies - University of Calgary
Michael Castaldo - University of British Columbia
Patrick J McNamara - University of Iowa
Resource Type: Journal article
Publication Details: Journal of perinatology
DOI: 10.1038/s41372-026-02670-5
PMID: 41981122
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Publisher: Springer
Grant note: Women and Children's Health Research Institute (Women & Children's Health Research Institute) BC Children's Hospital Research Institute (BCCHR)
Dr. Joseph Y. Ting was supported by Investigator Grant Award Program of British Columbia Children's Hospital Research Institute, Vancouver BC, Canada and Start-up funding from Women and Children's Health Research Institute of University of Alberta, Edmonton AB, Canada.
Language: English
Electronic publication date: 04/14/2026
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9985153359602771

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