Journal article
Echocardiography in experimentally-induced myocardial ischemia
The American journal of medicine, Vol.63(1), pp.21-28
1977
DOI: 10.1016/0002-9343(77)90114-0
PMID: 879194
Abstract
Using an experimental canine model, we have employed echocardiography to study segmental dyskinesis produced by acute coronary occlusion. Characteristic alterations in posterior wall and septal motion occur after acute coronary ligation; these resemble clinical abnormalities described in acute and old myocardial infarction. The degree of dyskinesis produced is directly related to the severity of the perfusion deficit. Coronary reperfusion had variable effects on dyskinesis; most animals showed improvement but in some the myocardial contraction abnormalities became more severe. A variety of interventions were undertaken during ischemia. The elevated level of arterial pressure induced by the administration of methoxamine increased ventricular diameter and presumably oxygen requirements, and was deleterious to ischemic wall motion whereas the administration of norepinephrine reduced ventricular diameter and improved function. Intra-aortic balloon counterpulsation had little effect on either ischemic motion or perfusion. These experimental studies generally support conclusions drawn from clinical echocardiograms about the relationship of abnormalities of wall motion to coronary artery lesions and myocardial ischemia, and suggest further clinical uses for echocardiography in coronary disease.
Details
- Title: Subtitle
- Echocardiography in experimentally-induced myocardial ischemia
- Creators
- Richard E KerberMelvin L MarcusFrancois M Abboud
- Resource Type
- Journal article
- Publication Details
- The American journal of medicine, Vol.63(1), pp.21-28
- DOI
- 10.1016/0002-9343(77)90114-0
- PMID
- 879194
- NLM abbreviation
- Am J Med
- ISSN
- 0002-9343
- eISSN
- 1555-7162
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1977
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025428702771
Metrics
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