Journal article
Ectopic pregnancy risk with assisted reproductive technology procedures
Obstetrics and gynecology (New York. 1953), Vol.107(3), pp.595-604
03/01/2006
DOI: 10.1097/01.AOG.0000196503.78126.62
PMID: 16507930
Abstract
To assess the ectopic pregnancy risk among women who conceived with assisted reproductive technology (ART) procedures.
The ectopic rate for ART pregnancies was calculated from population-based data of pregnancies conceived with ART in U.S. clinics in 1999-2001. Variation in ectopic risk by patient and ART treatment factors was assessed by using bivariate analyses and multivariable logistic regression.
Of 94,118 ART pregnancies, 2,009 (2.1%) were ectopic. Variation was observed by procedure type. In comparison with the ectopic rate (2.2%) among pregnancies conceived with in vitro fertilization and transcervical transfer of freshly fertilized embryos from the patient's oocytes (fresh, nondonor IVF-ET), the ectopic rate was significantly increased when zygote intrafallopian transfer (ZIFT) was used (3.6%) and significantly decreased when donor oocytes were used (1.4%) or when a gestational surrogate carried the pregnancy (0.9%). Among fresh nondonor IVF-ET procedures, the risk for ectopic pregnancy was increased among women with tubal factor infertility (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.7-2.4; referent group = ART for male factor), endometriosis (OR 1.3, 95% CI 1.0-1.6), and other nontubal female factors of infertility (OR 1.4, 95% CI 1.2-1.6) and decreased among women with a previous live birth (OR 0.6, 95% CI 0.5-0.7). Transfer of embryos with an indication of high implantation potential was associated with a decreased ectopic risk when 2 or fewer embryos were transferred (OR 0.7, 95% CI 0.5-0.9), but not when 3 or more embryos were transferred.
Ectopic risk among ART pregnancies varied according to ART procedure type, reproductive health characteristics of the woman carrying the pregnancy, and estimated embryo implantation potential.
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Details
- Title: Subtitle
- Ectopic pregnancy risk with assisted reproductive technology procedures
- Creators
- Heather B Clayton - National Center for Chronic Disease Prevention and Health PromotionLaura A Schieve - National Center for Chronic Disease Prevention and Health PromotionHerbert B Peterson - University of North Carolina at Chapel HillDenise J Jamieson - National Center for Chronic Disease Prevention and Health PromotionMeredith A Reynolds - National Center for Chronic Disease Prevention and Health PromotionVictoria C Wright - National Center for Chronic Disease Prevention and Health Promotion
- Resource Type
- Journal article
- Publication Details
- Obstetrics and gynecology (New York. 1953), Vol.107(3), pp.595-604
- DOI
- 10.1097/01.AOG.0000196503.78126.62
- PMID
- 16507930
- ISSN
- 0029-7844
- eISSN
- 1873-233X
- Language
- English
- Date published
- 03/01/2006
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446531202771
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