Journal article
Effect of β-blocker therapy in diabetic patients with stable coronary heart disease: a meta-analysis
Journal of geriatric cardiology : JGC, Vol.16(3), pp.291-301
03/2019
DOI: 10.11909/j.issn.1671-5411.2019.03.008
PMCID: PMC6500566
PMID: 31080472
Abstract
β-blocker (BB) therapy is a cornerstone for the treatment of coronary heart disease (CHD). The evidence of the benefit from long-term BB therapy in diabetic patients with stable CHD is scarce. This meta-analysis summarizes the evidence relating to the BB therapy in diabetic patients with stable CHD.
A meta-analysis was performed according to PRISMA and MOOSE guidelines for reporting of systematic reviews of observational studies. PubMed, Embase, and Cochrane central were searched and two authors independently screened studies for eligibility. The quality of studies was assessed with the Newcastle Ottawa scale. The primary outcome of interest was all-cause mortality, cardiovascular (CV) mortality and major adverse cardiovascular events (MACE) in diabetic patients with and without BB therapy. A generic inverse variance model was used to pool odds ratio or hazards ratio from included studies to calculate the overall effect estimate. The significance threshold was set at
-value < 0.05. Heterogeneity was assessed by
.
Four non-randomized studies with 9515 participants were selected for the analyses. Four studies were post-hoc analyses of randomized controlled trials, and one article was an analysis of a nationally representative survey. In a fixed effects model, BB therapy in diabetic patients with stable CHD was found to be associated with increased risk of CV mortality, and MACE (27% and 32% respectively;
-value < 0.05) and was not associated with a reduction in all-cause mortality (HR 1.12; 95% CI: 0.94-1.33;
-value = 0.22).
BB therapy in diabetic patients with stable CHD appears to be linked to higher mortality. Large randomized trials are needed in this population to confirm these findings.
Details
- Title: Subtitle
- Effect of β-blocker therapy in diabetic patients with stable coronary heart disease: a meta-analysis
- Creators
- Aaqib H Malik - Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY, USASuchith Shetty - Division of Cardiology, Department of Medicine, University of Iowa Health Care, Carver College of Medicine, Iowa, USAKausik Kar - Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY, USARamzi El Accaoui - Division of Cardiology, Department of Medicine, University of Iowa Health Care, Carver College of Medicine, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Journal of geriatric cardiology : JGC, Vol.16(3), pp.291-301
- DOI
- 10.11909/j.issn.1671-5411.2019.03.008
- PMID
- 31080472
- PMCID
- PMC6500566
- ISSN
- 1671-5411
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094209402771
Metrics
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