Effect of 4-META and 10-MDP primers on the adhesion of resin cement to conventional and translucent polycrystalline dental ceramics

Nathalia Elen Barbosa Dos Santos; Tainah Oliveira Rifane; Guilherme Magalhães Ribeiro; Vitaliano Gomes de Araujo Neto; Madiana Magalhães Moreira; Victor Pinheiro Feitosa; Tan Fırat Eyüboğlu; Mutlu Özcan; Diego Martins de Paula

doi:10.1186/s12903-026-08226-5

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Effect of 4-META and 10-MDP primers on the adhesion of resin cement to conventional and translucent polycrystalline dental ceramics

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Effect of 4-META and 10-MDP primers on the adhesion of resin cement to conventional and translucent polycrystalline dental ceramics

Nathalia Elen Barbosa Dos Santos, Tainah Oliveira Rifane, Guilherme Magalhães Ribeiro, Vitaliano Gomes de Araujo Neto, Madiana Magalhães Moreira, Victor Pinheiro Feitosa, Tan Fırat Eyüboğlu, Mutlu Özcan and Diego Martins de Paula

BMC oral health

04/01/2026

DOI: 10.1186/s12903-026-08226-5

PMID: 41917921

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Abstract

Background To evaluate the effect of different experimental primers containing 4-methacryloxyethyl trimellitate anhydride (4-META) and 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) on microshear bond strength (µSBS) and contact angle (CA) in different generations of zirconia. Methods Two experimental primers were prepared: 1 wt% 10-MDP in an ethanol-water solution and 1 wt% 4-META in an acetone-water solution. A commercial primer (Clearfil Ceramic Primer Plus) served as the control. Three zirconia types (3Y-TZP, 4Y-PSZ, 5Y-PSZ) were conditioned and bonded with RelyX ARC resin cement. µSBS (n = 6) was measured after 48 h and after 5,000 thermocycles, and fracture patterns were assessed. CA measurements (n = 8) were obtained using the sessile drop method. Data were analyzed using two-way ANOVA and Tukey’s test (α = 0.05). Results Immediate µSBS showed no differences among primers for 3Y-TZP and 4Y-PSZ (p > 0.05), whereas 10-MDP yielded higher values on 5Y-PSZ compared with 4-META (37.04 ± 5.60 MPa vs. 28.53 ± 4.62 MPa; p = 0.028). After aging, 4-META showed significantly lower µSBS on 5Y-PSZ (8.27 ± 7.56 MPa) than 10-MDP and control (p < 0.001). For contact angle, 4-META produced lower values on 5Y-PSZ than on 3Y-TZP and 4Y-PSZ (p < 0.001), while 10-MDP had the lowest CA on 3Y-TZP (p = 0.002). Adhesive failures predominated. Conclusions The 10-MDP primer showed stable bonding across all zirconia types, whereas 4-META exhibited reduced bonding stability, particularly on cubic-rich zirconias. These findings highlight the importance of zirconia composition and monomer chemistry in adhesion, indicating that simplified MDP-based formulations may provide effective bonding to high-translucency zirconias.

Zirconia

Prosthodtontics

Dental materials

Primers

Microshear bond strength

Ceramics

Adhesion

Details

Title: Subtitle: Effect of 4-META and 10-MDP primers on the adhesion of resin cement to conventional and translucent polycrystalline dental ceramics
Creators: Nathalia Elen Barbosa Dos Santos - Paulo Picanço School of Dentistry
Tainah Oliveira Rifane - Paulo Picanço School of Dentistry
Guilherme Magalhães Ribeiro - Paulo Picanço School of Dentistry
Vitaliano Gomes de Araujo Neto - Universidade Estadual de Campinas (UNICAMP)
Madiana Magalhães Moreira - Paulo Picanço School of Dentistry
Victor Pinheiro Feitosa - University of Iowa
Tan Fırat Eyüboğlu - University of Zurich
Mutlu Özcan - University of Zurich
Diego Martins de Paula - Paulo Picanço School of Dentistry
Resource Type: Journal article
Publication Details: BMC oral health
DOI: 10.1186/s12903-026-08226-5
PMID: 41917921
NLM abbreviation: BMC Oral Health
ISSN: 1472-6831
eISSN: 1472-6831
Publisher: Springer Nature
Language: English
Electronic publication date: 04/01/2026
Academic Unit: Operative Dentistry
Record Identifier: 9985149524002771

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