Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: results from the Women's Health Initiative

Swapnil N Rajpathak; Xiaonan Xue; Sylvia Wassertheil-Smoller; Linda Van Horn; Jennifer G Robinson; Simin Liu; Matthew Allison; Lisa W Martin; Gloria Y F Ho; Thomas E Rohan

doi:10.3945/ajcn.2009.28579

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Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: results from the Women's Health Initiative

Journal article

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Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: results from the Women's Health Initiative

Swapnil N Rajpathak, Xiaonan Xue, Sylvia Wassertheil-Smoller, Linda Van Horn, Jennifer G Robinson, Simin Liu, Matthew Allison, Lisa W Martin, Gloria Y F Ho and Thomas E Rohan

The American journal of clinical nutrition, Vol.91(4), pp.894-899

04/2010

DOI: 10.3945/ajcn.2009.28579

PMCID: PMC2844677

PMID: 20181812

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Abstract

Dietary calcium and vitamin D intakes may be inversely associated with cardiovascular disease (CVD) risk, possibly because of their potential beneficial effects on circulating lipids. Clinical trials that have evaluated the effect of calcium supplementation on lipids are limited by a short follow-up, and data on vitamin D are scarce. The objective was to evaluate the effect of a longer-term effect (over 5 y) of calcium and vitamin D (CaD) supplementation on changes in the concentrations of several lipids: LDL, HDL, non-HDL, total cholesterol, triglycerides, and lipoprotein(a) [Lp(a)]. The study was conducted in 1259 postmenopausal women in the Calcium plus Vitamin D Trial (1 g elemental Ca as carbonate plus 400 IU vitamin D(3)/d compared with placebo) of the Women's Health Initiative. Analyses were conducted by intention-to-treat. Repeated measurements on lipids during follow-up were analyzed by linear mixed-effects models. Overall, the change in lipids was relatively small [< or =5% except for Lp(a), which was 20-25%], and there was no significant difference in the mean change of any lipid variable between the active and placebo groups. Our results indicate that CaD supplementation is not associated with lipid changes over 5 y. Existing and future CaD trials should consider evaluating this association for different doses of supplements. This study was registered at clinicaltrials.gov as NCT00000611.

Cardiovascular Diseases - etiology

Calcium - pharmacology

Women's Health

Cardiovascular Diseases - prevention & control

Humans

Middle Aged

Calcium - administration & dosage

Vitamin D - pharmacology

Micronutrients - pharmacology

Lipids - blood

Postmenopause

Female

Vitamin D - administration & dosage

Aged

Lipoprotein(a) - blood

Drug Therapy, Combination

Dietary Supplements

Details

Title: Subtitle: Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: results from the Women's Health Initiative
Creators: Swapnil N Rajpathak - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. swapnil.rajpathak@einstein.yu.edu
Xiaonan Xue
Sylvia Wassertheil-Smoller
Linda Van Horn
Jennifer G Robinson
Simin Liu
Matthew Allison
Lisa W Martin
Gloria Y F Ho
Thomas E Rohan
Resource Type: Journal article
Publication Details: The American journal of clinical nutrition, Vol.91(4), pp.894-899
Publisher: United States
DOI: 10.3945/ajcn.2009.28579
PMID: 20181812
PMCID: PMC2844677
ISSN: 0002-9165
eISSN: 1938-3207
Grant note: N01WH22110, / WHI NIH HHS
Language: English
Date published: 04/2010
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995020302771

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