Journal article
Effect of 9-alpha-fluorohydrocortisone on forearm venous responses to norepinephrine and tyramine
Journal of applied physiology (1985), Vol.23(4), pp.571-574
10/1967
DOI: 10.1152/jappl.1967.23.4.571
PMID: 6053685
Abstract
Forearm venous responses to norepinephrine and to tyramine were studied in seven subjects treated for 1 week with Scr-fluorohydrocortisone, 1 mg initially and 0.2 mg daily. The drug was given orally. Control observations were made 3 weeks after stopping treatment. Venous tone was calculated from measurements of forearm volume at a transmural venous pressure of 30 mm Hg during brachial artery infusions of norepinephrine in doses of 0.0375, 0.075, and 0.15 pg/min and tyramine in doses of 9, 18, and 36 pg/min. The ratio of the dose of norepinephrine which gave a certain venous response during the control period to the dose which gave the same response after treatment with Sa-fluorohydrocortisone was 1.442. The corresponding ratio for tyramine was 1.453. In these experiments the effects of norepinephrine and tyramine were potentiated by treatment with Sa-fluorohydrocortisone, This potentiation did not appear to be related to an effect of the steroid on endogenous norepinephrine stores since the responses to both norepinephrine and tyramine were increased by the same magnitude.
Details
- Title: Subtitle
- Effect of 9-alpha-fluorohydrocortisone on forearm venous responses to norepinephrine and tyramine
- Creators
- Phillip G SchmidJohn W EcksteinFrancois M Abboud
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.23(4), pp.571-574
- DOI
- 10.1152/jappl.1967.23.4.571
- PMID
- 6053685
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 10/1967
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025443302771
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