Journal article
Effect of Age and Acute Exercise on Circulating Angioregulatory Factors
Journal of aging and physical activity, Vol.29(3), pp.423-430
06/01/2021
DOI: 10.1123/japa.2020-0024
PMID: 33091872
Abstract
The balance of angiogenic factors, including vascular endothelial growth factor (VEGF), and angiostatic factors, like thrombospondin-1 (TSP-1) and endostatin, controls striatedmuscle angiogenic responses to exercise training. The effect of age on circulating levels of these factors following a bout of exercise is unclear. The authors hypothesized that older adults would have lower circulating VEGF but higher TSP-1 and endostatin after exercise compared with young adults. Ten young and nine older participants cycled for 45 min at 60% estimated HRmax. Serum [VEGF], [TSP-1], and [endostatin] obtained before (PREX), immediately after (POSTX0), and 3 hr after (POSTX3) exercise were analyzed. [VEGF] increased in older adults only from PREX to POSTX0 (p < .05). [TSP-1] increased in both age groups (p <.05). There was no effect of age or exercise on [endostatin]. In conclusion, immediately after exercise, both groups had a similar increase in [TSP-1], but [VEGF] increased in older adults only.
Details
- Title: Subtitle
- Effect of Age and Acute Exercise on Circulating Angioregulatory Factors
- Creators
- Meredith J. Luttrell - Drake UniversityBenjamin R. Mardis - Drake UniversityJoshua M. Bock - Univ Iowa, Carver Coll Med, Dept Phys Therapy & Rehabil Sci, Iowa City, IA USAErika Iwamoto - Univ Iowa, Carver Coll Med, Dept Phys Therapy & Rehabil Sci, Iowa City, IA USASatoshi Hanada - Univ Iowa, Dept Anesthesia, Carver Coll Med, Iowa City, IA 52242 USAKenichi Ueda - Univ Iowa, Dept Anesthesia, Carver Coll Med, Iowa City, IA 52242 USAAndrew J. Feider - Univ Iowa, Dept Anesthesia, Carver Coll Med, Iowa City, IA 52242 USAKenzie Temperly - Drake UniversityDarren Casey - Univ Iowa, Carver Coll Med, Dept Phys Therapy & Rehabil Sci, Iowa City, IA USA
- Resource Type
- Journal article
- Publication Details
- Journal of aging and physical activity, Vol.29(3), pp.423-430
- Publisher
- Human Kinetics Publ Inc
- DOI
- 10.1123/japa.2020-0024
- PMID
- 33091872
- ISSN
- 1063-8652
- eISSN
- 1543-267X
- Number of pages
- 8
- Grant note
- University of Iowa Carver College of Medicine FUTURE in Biomedicine Program Fellowship Drake University College of Arts and Sciences Office of the Dean Drake University College of Arts and Sciences Faculty Development Grant
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Anesthesia; Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984295059102771
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