Journal article
Effect of Antiretroviral Therapy and Hepatitis C Co-infection on Changes in Lipid Levels in HIV-Infected Patients 48 Weeks After Initiation of Therapy
HIV clinical trials, Vol.8(6), pp.429-436
12/01/2007
DOI: 10.1310/hct0806-429
PMID: 18042508
Abstract
Hepatitis C virus (HCV) commonly co-infects HIV-infected individuals. Antiretroviral therapy (ART) is associated with elevated serum lipid levels, and HCV infection is associated with low serum lipid levels. Fasting lipid levels were investigated in 1,434 ART-naïve HIV-infected people participating in the AIDS Clinical Trials Group (ACTG) Longitudinal Linked Randomized Trials (ALLRT) protocol who prospectively initiated ART with ≥3 agents. Subjects with elevated liver-associated enzymes (>5 × ULN) were excluded. Demographics, body mass index, HCV status, CD4 cell count, HIV RNA, liver enzymes, lipid levels, and glucose were assessed before and following 48 weeks of ART. HCV-positive subjects (n = 160; 11%) were older, more likely to be Black, have a history of intravenous drug use (IDU), have higher baseline liver-associated enzyme levels than the HCV-negative group (p < .001 for each), and to have diabetes at baseline (5% vs. 2%, p = .07). Lipid levels rose in both groups following ART, and the differences were not significant except that HDL levels increased significantly more in the HCV-positive group (p = .006). In summary, HCV infection did not appear to provide significant protection against ART-induced hyperlipidemia in this cohort of HIV-infected subjects prospectively enrolled in ART trials, although HDL levels rose to a greater degree.
Details
- Title: Subtitle
- Effect of Antiretroviral Therapy and Hepatitis C Co-infection on Changes in Lipid Levels in HIV-Infected Patients 48 Weeks After Initiation of Therapy
- Creators
- J. T Stapleton - Iowa City VA Medical Center and the University of IowaK Bennett - Statistical & Data Analysis CenterHarvard School of Public HealthR. J Bosch - Statistical & Data Analysis CenterHarvard School of Public HealthP. M Polgreen - Iowa City VA Medical Center and the University of IowaS Swindells - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- HIV clinical trials, Vol.8(6), pp.429-436
- DOI
- 10.1310/hct0806-429
- PMID
- 18042508
- NLM abbreviation
- HIV Clin Trials
- ISSN
- 1528-4336
- eISSN
- 1945-5771
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 12/01/2007
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984094379002771
Metrics
15 Record Views