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Effect of Aspirin Supplementation on Hemodynamics in Older Firefighters
Journal article   Open access   Peer reviewed

Effect of Aspirin Supplementation on Hemodynamics in Older Firefighters

Abbi D. Lane-Cordova, Sushant M. Ranadive, Huimin Yan, Rebecca M. Kappus, Peng Sun, Kanokwan Bunsawat, Denise L. Smith, Gavin P. Horn, Robert Ploutz-Snyder and Bo Fernhall
Medicine and science in sports and exercise, Vol.47(12), pp.2653-2659
12/01/2015
DOI: 10.1249/MSS.0000000000000713
PMID: 26057939
url
https://doi.org/10.1249/MSS.0000000000000713View
Published (Version of record) Open Access

Abstract

Purpose: Cardiovascular events are the leading cause of line-of-duty fatality for firefighters. Aspirin reduces the risk of cardiovascular events in men and may reduce fatalities in older ( 940 yr) firefighters. We hypothesized that both chronic and acute aspirin supplementation would improve vascular function after live firefighting but that chronic supplementation would also improve resting hemodynamics. Methods: Twenty- four firefighters ( 40- 60 yr) were randomly assigned to acute or chronic aspirin supplementation or placebo in a balanced, crossover design. Arterial stiffness, brachial and central blood pressures, as well as forearm vasodilatory capacity and blood flow were measured at rest and immediately after live firefighting. Results: Total hyperemic blood flow ( area under the curve ( AUC)) was increased ( P< G 0.001) after firefighting with no effects for aspirin supplementation or acute versus chronic administration ( AUC, from 107 +/- 5 to 223 +/- 9 in aspirin condition and from 97 +/- 5 to 216 +/- 7 mL.min -1 per 100-mL forearm tissue for placebo; P< G 0.05 for main, and P> 9 0.05 for interaction). Arterial stiffness/central blood pressure increased ( P< G 0.04) with no effect of aspirin ( from 0.0811 +/- 0.001 to 0.0844 +/- 0.003 ms-1 mm Hg-1 in aspirin condition versus 0.0802 +/- 0.002 to 0.0858 +/- 0.002 ms-1 Imm Hg-1 in placebo condition), whereas peripheral and central systolic and pulse pressures decreased after firefighting across conditions ( P< 0.05). Conclusions: Live firefighting resulted in increased AUC and pressure-controlled arterial stiffness and decreased blood pressure in older firefighters, but aspirin supplementation did not affect macroor microvascular responsiveness at rest or after firefighting.
 Life Sciences & Biomedicine Science & Technology Sport Sciences

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