Journal article
Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.76(11), pp.2007-2014
10/13/2021
DOI: 10.1093/gerona/glaa316
PMCID: PMC8514067
PMID: 33367621
Abstract
Cerebrovascular events, dementia, and cancer can contribute to physical disability with activities of daily living (ADL). It is unclear whether low-dose aspirin reduces this burden in aging populations. In a secondary analysis, we now examine aspirin's effects on incident and persistent ADL disability within a primary prevention aspirin trial in community-dwelling older adults.
The ASPREE (ASPirin in Reducing Events in the Elderly) trial of daily 100 mg aspirin versus placebo recruited 19 114 healthy adults aged 70+ years (65+ years if U.S. minority) in Australia and the United States. Six basic ADLs were assessed every 6 months. Incident ADL disability was defined as inability or severe difficulty with ≥1 ADL; persistence was confirmed if the same ADL disability remained after 6 months. Proportional hazards modeling compared time to incident or persistent ADL disability for aspirin versus placebo; death without prior disability was a competing risk.
Over a median of 4.7 years, incident ADL disability was similar in those receiving aspirin (776/9525) and placebo (787/9589) with walking, bathing, dressing, and transferring the most commonly reported. Only 24% of incident ADL disability progressed to persistent. Persistent ADL disability was lower in the aspirin group (4.3 vs 5.3 events/1000 py; hazard ratio [HR] = 0.81, 95% confidence interval [CI]: 0.66-1.00), with bathing and dressing the most common ADL disabilities in both groups. Following persistent ADL disability, there were more deaths in the aspirin group (24 vs 12).
Low-dose aspirin in initially healthy older people did not reduce the risk of incident ADL disability, although there was evidence of reduced persistent ADL disability.
Details
- Title: Subtitle
- Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults
- Creators
- Robyn L Woods - Monash UniversitySara Espinoza - South Texas Veterans Health Care SystemLe T P Thao - Monash UniversityMichael E Ernst - University of IowaJoanne Ryan - Monash UniversityRory Wolfe - Monash UniversityRaj C Shah - Rush University Medical CenterStephanie A Ward - UNSW SydneyElsdon Storey - Monash UniversityMark R Nelson - University of TasmaniaChristopher M Reid - Curtin UniversityJessica E Lockery - Monash UniversitySuzanne G Orchard - Monash UniversityRuth E Trevaks - Monash UniversitySharyn M Fitzgerald - Monash UniversityNigel P Stocks - University of AdelaideJeff D Williamson - Wake Forest UniversityJohn J McNeil - Monash UniversityAnne M Murray - Hennepin County Medical CenterAnne B Newman - University of PittsburghASPREE Investigator Group
- Resource Type
- Journal article
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.76(11), pp.2007-2014
- DOI
- 10.1093/gerona/glaa316
- PMID
- 33367621
- PMCID
- PMC8514067
- ISSN
- 1079-5006
- eISSN
- 1758-535X
- Grant note
- U01 AG029824 / NIA NIH HHS U01AG029824 / NIH HHS P30 AG024832 / NIA NIH HHS P30 AG024824 / NIA NIH HHS NCI NIH HHS
- Language
- English
- Date published
- 10/13/2021
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297446702771
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