Effect of Atriopeptin on Production of Cerebrospinal Fluid

Kimberly A Schalk; Frank M Faraci; John L Williams; Dianna VanOrden; Donald D Heistad

doi:10.1038/jcbfm.1992.94

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Effect of Atriopeptin on Production of Cerebrospinal Fluid

Journal article

Open access

Peer reviewed

Effect of Atriopeptin on Production of Cerebrospinal Fluid

Kimberly A Schalk, Frank M Faraci, John L Williams, Dianna VanOrden and Donald D Heistad

Journal of cerebral blood flow and metabolism, Vol.12(4), pp.691-696

06/29/2016

DOI: 10.1038/jcbfm.1992.94

PMID: 1535632

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Abstract

We reported previously that intravenous infusion of atriopeptin increases blood flow to the choroid plexus. The first goal of this study was to determine whether blood-borne atriopeptin increases the production of CSF. Ventriculocisternal perfusion was used to measure the production of CSF in anesthetized rabbits. Atriopeptin increased blood flow to the choroid plexus (measured with microspheres) but did not alter the production of CSF. The second goal of the study was to determine whether intracerebroventricular injection of atriopeptin affects the production of CSF. Injection of atriopeptin into the cerebral ventricles increased blood flow to the choroid plexus but produced a small decrease in production of CSF. In summary, blood-borne and intraventricular atriopeptin increase blood flow to the choroid plexus, but do not increase the production of CSF.

Details

Title: Subtitle: Effect of Atriopeptin on Production of Cerebrospinal Fluid
Creators: Kimberly A Schalk - Departments of Internal Medicine, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.A., Departments of Anatomy, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.A
Frank M Faraci - Departments of Internal Medicine, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.A., Departments of Pharmacology, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.A
John L Williams - Departments of Internal Medicine, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.A
Dianna VanOrden - Departments of Internal Medicine, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.A
Donald D Heistad - Departments of Internal Medicine, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.A., Departments of Pharmacology, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.A
Resource Type: Journal article
Publication Details: Journal of cerebral blood flow and metabolism, Vol.12(4), pp.691-696
DOI: 10.1038/jcbfm.1992.94
PMID: 1535632
ISSN: 0271-678X
eISSN: 1559-7016
Language: English
Date published: 06/29/2016
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040575802771

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