Journal article
Effect of Chronic Hypertension and Sympathetic Denervation on Wall/Lumen Ratio of Cerebral Vessels
Hypertension (Dallas, Tex. 1979), Vol.2(4), pp.419-423
07/1980
DOI: 10.1161/01.HYP.2.4.419
PMID: 7399625
Abstract
SUMMARY The purposes of this study were to determine whether 1) cerebral vessels undergo hypertrophy during chronic hypertension and 2) sympathetic nenes contribute to cerebral vascular changes In chronic hypertension. Morphometiic studies were undertaken in stroke-prone spontaneously hypertensive rats (SP-SHR) and normotenslve Wistar-Kyoto (WKY) rats. Unilateral superior cerrical gangUonectomy was performed in the SP-SHR at 8 weeks of age. When the rats were approximately 13 months old, they were killed and the brain was fixed with formalin at a perfusion pressure of 80% of the ratʼs systolic pressure. Wall/lumen ratio was measured in approximately 1200 arteries and arterioles. In parenchymal, but not pial, cerebral vessels there was pronounced vascular hypertrophy in SP-SHRwall/lumen ratio was 0.08 in WKY and 0.14 in SP-SHR (p < 0.05). Sympathetic denervation attenuated the development of vascular hypertrophy in SP-SHRwall/lumen ratio was 0.14 in the innervated parenchymal vessels, and 0.10 in denervated vessels (p < 0.05). We conclude that cerebral vessels undergo hypertrophy in stroke-prone SHR and speculate that vascular hypertrophy may protect cerebral vessels by reducing wall stress in chronic hypertension. Sympathetic nerves appear to exert a trophic effect on cerebral vascular muscle in chronic hypertension.
Details
- Title: Subtitle
- Effect of Chronic Hypertension and Sympathetic Denervation on Wall/Lumen Ratio of Cerebral Vessels
- Creators
- MICHAEL HART - From the Departments of Pathology, Internal Medicine, and Pharmacology and Cardiovascular Center, University of Iowa College of Medicine and VA Hospital, Iowa City, IowaDONALD HEISTADMICHAEL BRODY
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.2(4), pp.419-423
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.HYP.2.4.419
- PMID
- 7399625
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 07/1980
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040321802771
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