Journal article
Effect of CpG DNA oligodeoxynucleotides and echinacea on the fungicidal activity of amphotericin B in a disseminated murine candidal infection model
Journal of infectious disease pharmacotherapy, Vol.4(4), pp.55-66
01/01/2001
DOI: 10.1300/J100v04n04_05
Abstract
We evaluated the impact of adjuvant CpG DNA and echinacea on the fungicidal activity of amphotericin B in a murine model. Two infection models were utilized, a non-neutropenic treatment model and a neutropenic protection model. Groups evaluated included; control, CpG, echinacea, amphotericin B, echinacea plus amphotericin B, and CpG plus amphotericin B. Balb-C mice were systemically infected with C. albicans. In the non-neutropenic treatment model, beginning four or twelve hours after infection, mice were administered echinacea, 130 mg/kg every twelve hours for 72 hours, CpG, 30 mu g once, amphotericin B 1 mg/kg, or combinations of echinacea or CpG with amphotericin B. Kidney fungal burden was determined. In the neutropenic protection model CpG was administered 72 hours prior to infection and echinacea was started 24 hours prior to infection and continued 72 hours post-infection. Mortality was assessed for 10 days. Among non-neutropenic mice, no decrease in tissue fungal burden was noted with CpG or echinacea compared to control. Echinacea or CpG plus amphotericin B did not additionally decrease fungal burden. Among neutropenic mice, neither CpG nor echinacea administered alone or in combination with amphotericin B improved survival compared to control or amphotericin B, respectively.
Details
- Title: Subtitle
- Effect of CpG DNA oligodeoxynucleotides and echinacea on the fungicidal activity of amphotericin B in a disseminated murine candidal infection model
- Creators
- H HoffmanE ErnstThW RedfordM E Klepser
- Resource Type
- Journal article
- Publication Details
- Journal of infectious disease pharmacotherapy, Vol.4(4), pp.55-66
- DOI
- 10.1300/J100v04n04_05
- ISSN
- 1068-7777
- eISSN
- 1540-711X
- Language
- English
- Date published
- 01/01/2001
- Academic Unit
- Pharmacy Practice and Science
- Record Identifier
- 9984366041602771
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