Journal article
Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats
Journal of diabetes research, Vol.2018, pp.2967127-9
01/01/2018
DOI: 10.1155/2018/2967127
PMCID: PMC6051246
PMID: 30057911
Abstract
In this study, we wanted to extend our investigation of the efficacy of fish oil with or without salsalate on vascular and neural complications using a type 2 diabetic rat model. Four weeks after the onset of hyperglycemia, diabetic rats were treated via the diet with 3 different amounts of menhaden oil with or without salsalate for 12 weeks. Afterwards, vascular reactivity of epineurial arterioles and neuropathy-related endpoints were examined. The addition of salsalate to high-fat diets enriched with 10% or 25% kcal of menhaden oil protected vascular reactivity to acetylcholine and calcium gene-related peptide, motor and sensory nerve conduction velocity, thermal nociception, intraepidermal nerve fiber density, and cornea sensitivity to a greater extent than 10% or 25% menhaden oil alone. Vascular and neural function was maximally protected with diet containing 45% kcal as menhaden oil, and adding salsalate did not provide any additional benefit. Salsalate alone in the high-fat diet of diabetic rats provided minimal protection/improvement of vascular and neural dysfunction. These studies imply that dietary salsalate in combination with lower amounts of menhaden oil can provide greater benefit toward diabetes-induced vascular and neural impairment than menhaden oil alone.
Details
- Title: Subtitle
- Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats
- Creators
- Eric P. Davidson - University of IowaLawrence J. Coppey - University of IowaHanna Shevalye - University of IowaAlexander Obrosov - University of IowaMark A. Yorek - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of diabetes research, Vol.2018, pp.2967127-9
- DOI
- 10.1155/2018/2967127
- PMID
- 30057911
- PMCID
- PMC6051246
- NLM abbreviation
- J Diabetes Res
- ISSN
- 2314-6745
- eISSN
- 2314-6753
- Publisher
- Hindawi Publishing Group
- Number of pages
- 9
- Grant note
- DK107339-03 / National Institute of Diabetes and Digestive and Kidney Diseases from NIH R01DK107399 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) RX000889-06 / Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, and Rehabilitation Research and Development Service; US Department of Veterans Affairs I01RX000889 / Veterans Affairs; US Department of Veterans Affairs
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984359666602771
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