Journal article
Effect of Digoxin and Amino Sugar Cardiac Glycoside (ASI-222) on Plasma Antidiuretic Hormone Activity
Journal of cardiovascular pharmacology, Vol.4(5), pp.730-737
09/1982
DOI: 10.1097/00005344-198209000-00006
PMID: 6182402
Abstract
SUMMARYDigoxin acts at central neural (CNS) as well as peripheral sites after intravenous administration. In contrast, the analog, 3-B-O(4-amino-4,6-dideoxy-B-D-galactopyranosyl)-digitoxigenin (ASI-222), cannot cross the blood–brain barrier so it acts only at sites outside the CNS. The effects of these two agents on plasma antidiuretic hormone activity (ADH) were investigated in conscious dogs. Despite previous evidence that digoxin produces reflex decreases in sympathetic nerve activity by activating ventricular receptors with vagal afferents, no decreases in ADH were detected when either digoxin (25 and 50 μg/kg) or ASI-222 (38.5 μg/kg) were administered intravenously even with preexisting high levels of plasma ADH. In contrast, both digoxin (50 μg/kg) and ASI-222 (38.5 μg/kg) resulted in increased ADH levels, but only in association with emesis and behavioral changes suggestive of nausea. Cerebroventricular (IVT) injections of digoxin were given, starting with a dose of 0.1 μg. that were intended to produce a comparable cerebrospinal fluid (CSF) concentration to that associated with the 50 μg/kg intravenous dose. Only the highest dose of digoxin, 1 μg, but not 0.1 and 0.3 μg, produced increases in ADH and emesis when given into the lateral cerebral ventricle. This is further evidence that a site accessible to blood but not to CSF was involved. These results suggest that digoxin and ASI-222 may activate pathways in the area postrema and produce increases in ADH as well as emesis.
Details
- Title: Subtitle
- Effect of Digoxin and Amino Sugar Cardiac Glycoside (ASI-222) on Plasma Antidiuretic Hormone Activity
- Creators
- Gary Guo - Cardiovascular Center, Department of Medicine, University of Iowa: and Veterans Administration Medical Center, Iowa City, IowaPhillip SchmidFrançois Abboud
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular pharmacology, Vol.4(5), pp.730-737
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00005344-198209000-00006
- PMID
- 6182402
- ISSN
- 0160-2446
- eISSN
- 1533-4023
- Language
- English
- Date published
- 09/1982
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025596502771
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