Effect of Enhanced External Counterpulsation on Inflammatory Cytokines and Adhesion Molecules in Patients With Angina Pectoris and Angiographic Coronary Artery Disease

Darren P Casey; C. Richard Conti; Wilmer W Nichols; Calvin Y Choi; Matheen A Khuddus; Randy W Braith

doi:10.1016/j.amjcard.2007.08.031

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Effect of Enhanced External Counterpulsation on Inflammatory Cytokines and Adhesion Molecules in Patients With Angina Pectoris and Angiographic Coronary Artery Disease

Journal article

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Effect of Enhanced External Counterpulsation on Inflammatory Cytokines and Adhesion Molecules in Patients With Angina Pectoris and Angiographic Coronary Artery Disease

Darren P Casey, C. Richard Conti, Wilmer W Nichols, Calvin Y Choi, Matheen A Khuddus and Randy W Braith

The American journal of cardiology, Vol.101(3), pp.300-302

2008

DOI: 10.1016/j.amjcard.2007.08.031

PMCID: PMC2276610

PMID: 18237588

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http://doi.org/10.1016/j.amjcard.2007.08.031View

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Abstract

Cardiovascular disease is associated with chronic low-level inflammation, as evidenced by elevated circulating proinflammatory cytokines. Experimental evidence suggests that inflammation can be suppressed under conditions of high shear stress. This study was conducted to examine the effects of enhanced external counterpulsation (EECP), a noninvasive therapy that increases endothelial shear stress, on circulating levels of inflammatory biomarkers and adhesion molecules in patients with angina pectoris. Twenty-one patients were randomly assigned to either 35 1-hour treatments at cuff pressures of 300 mm Hg (EECP; n = 12) or 75 mm Hg (sham; n = 9). Plasma tumor necrosis factor–α, monocyte chemoattractant protein–1, and soluble vascular cell adhesion molecule–1 were measured before and after 35 1-hour sessions of treatment or sham. Patients in the EECP group demonstrated reductions in tumor necrosis factor-α (6.9 ± 2.7 vs 4.9 ± 2.5 pg/ml, p <0.01; −29%) and monocyte chemoattractant protein–1 (254.9 ± 55.9 vs 190.4 ± 47.6 pg/ml, p <0.01; −19%) after treatment, whereas there was no change in the sham group. Changes in soluble vascular cell adhesion molecule–1 were not observed in either group. In conclusion, 35 sessions of EECP decreased circulating levels of proinflammatory biomarkers in patients with symptomatic coronary artery disease.

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Title: Subtitle: Effect of Enhanced External Counterpulsation on Inflammatory Cytokines and Adhesion Molecules in Patients With Angina Pectoris and Angiographic Coronary Artery Disease
Creators: Darren P Casey - Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida
C. Richard Conti - Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, Florida
Wilmer W Nichols - Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, Florida
Calvin Y Choi - Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, Florida
Matheen A Khuddus - Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, Florida
Randy W Braith - Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida
Resource Type: Journal article
Publication Details: The American journal of cardiology, Vol.101(3), pp.300-302
DOI: 10.1016/j.amjcard.2007.08.031
PMID: 18237588
PMCID: PMC2276610
NLM abbreviation: Am J Cardiol
ISSN: 0002-9149
eISSN: 1879-1913
Publisher: Elsevier Inc
Language: English
Date published: 2008
Academic Unit: Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984047775902771

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