Journal article
Effect of Erythropoietin and Stem Cells on Traumatic Brain Injury
World neurosurgery, Vol.89, pp.355-367
05/01/2016
DOI: 10.1016/j.wneu.2016.01.040
PMID: 26850972
Abstract
OBJECTIVE: To investigate the healing effects of erythropoietin (EPO) and stem cells (SCs) in traumatic brain injury (TBI).
METHODS: Twenty-nine Wistar albino rats were used and separated into the following groups: control (C), EPO, SC, and SC+EPO. Group C received a TBI only, with no treatment. In the EPO group, 1000 U/kg EPO was given intraperitoneally at 30 minutes after TBI. In SC group, immediately after formation of TBI, 3 x 10,000 CD34(+) stem cells were injected into the affected area. In the SC+EPO group, half an hour after TBI and the injection of stemcells, 1000 U/kg EPO was injected. Before and after injury, trauma coordination performance was measured by the rotarod and inclined plane tests.
RESULTS: Seven weeks after trauma, rat brains were examined by radiology and histology. Rotarod performance test did not change remarkably, even after the injury. Compared with group C, the SC+EPO group was found to have significant differences in the inclined plane test results.
CONCLUSIONS: Separately given, SCs and EPO have a positive effect on TBI, and our findings suggest that their coadministration is even more powerful.
Details
- Title: Subtitle
- Effect of Erythropoietin and Stem Cells on Traumatic Brain Injury
- Creators
- Melek Tunc Ata - Pamukkale UniversityGunfer Turgut - Pamukkale UniversityMetin Akbulut - Pamukkale UniversityAli Kocyigit - Pamukkale UniversityAysun Karabulut - Pamukkale UniversityHande Senol - Pamukkale UniversitySebahat Turgut - Pamukkale University
- Resource Type
- Journal article
- Publication Details
- World neurosurgery, Vol.89, pp.355-367
- DOI
- 10.1016/j.wneu.2016.01.040
- PMID
- 26850972
- NLM abbreviation
- World Neurosurg
- ISSN
- 1878-8750
- eISSN
- 1878-8769
- Publisher
- Elsevier
- Number of pages
- 13
- Language
- English
- Date published
- 05/01/2016
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9985123940602771
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