Journal article
Effect of Estrogen/Progestin Potency on Lipid/Lipoprotein Cholesterol
The New England journal of medicine, Vol.308(15), pp.862-867
04/14/1983
DOI: 10.1056/NEJM198304143081502
PMID: 6572785
Abstract
Abstract We studied 374 women taking oral contraceptives, 284 women taking estrogen preparations after menopause, and 1086 women taking no hormones, to determine the relation of plasma lipids and lipoprotein cholesterol concentrations to various types of estrogen/progestin formulations. Premenopausal women, using oral contraceptives containing a relatively low dose of estrogen combined with a medium or high dose of progestin (Norlestrin, Ovral, or Demulen) had a 24 per cent higher median concentration of low-density-lipoprotein cholesterol than did those not using hormones (P<0.05). Women using oral contraceptives that are high in estrogen and low in progestin (Enovid or Oracon) had significantly higher concentrations of high-density-lipoprotein cholesterol than did nonusers; those using Ovral, a low-estrogen and high-progestin formulation, had significantly lower levels of high-density-lipoprotein cholesterol. In postmenopausal women the use of estrogen was associated with concentrations of low-density-lipoprotein cholesterol that were 11 to 19 per cent below the levels in postmenopausal women who did not use hormones. The effects of estrogen-progestin balance on low-density and high-density lipoproteins may underlie the increased incidence of stroke and myocardial infarction in women of childbearing age who take oral contraceptives. (N Engl J Med. 1983; 308: 862-7.)
Details
- Title: Subtitle
- Effect of Estrogen/Progestin Potency on Lipid/Lipoprotein Cholesterol
- Creators
- Patricia Wahl - University of WashingtonCarolyn Walden - University of WashingtonRobert Knopp - University of WashingtonJoanne HooverRobert Wallace - University of WashingtonGerardo Heiss - University of WashingtonBasil Rifkind - University of Washington
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.308(15), pp.862-867
- DOI
- 10.1056/NEJM198304143081502
- PMID
- 6572785
- NLM abbreviation
- N Engl J Med
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Publisher
- Massachusetts Medical Society
- Language
- English
- Date published
- 04/14/1983
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363605302771
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