Journal article
Effect of FK506 on peripheral nerve regeneration through long grafts in inbred swine
Annals of plastic surgery, Vol.54(4), pp.420-427
04/01/2005
DOI: 10.1097/01.sap.0000151461.60911.c0
PMID: 15785285
Abstract
Numerous small-animal studies have demonstrated that FK506 enhances nerve regeneration and accelerates functional recovery after nerve injury. However, no experimental study has corroborated these neuroregenerative effects in larger animals. This study investigated the effects of FK506 on nerve regeneration in inbred miniature swine. Eight animals received 8-cm ulnar nerve autografts and allografts. Treated animals received 0.1 to 0.4 mg/kg FK506 injections twice weekly to maintain immunosuppressive serum FK506 levels. At 24 weeks posttransplant, nerve grafts were harvested for histomorphometric analysis. Mixed lymphocyte cultures demonstrated alloreactivity in 1 treated animal and all untreated animals. In autografts, mean fiber count, nerve density, and percent neural tissue were doubled with FK506 therapy. In allografts, significant neuroregeneration was observed in animals treated with FK506, whereas untreated animals had no regeneration. Treatment with FK506 resulted in a trend toward enhanced axonal regeneration through nerve autografts and allografts in a large-animal model with defined histocompatibility barriers.
Details
- Title: Subtitle
- Effect of FK506 on peripheral nerve regeneration through long grafts in inbred swine
- Creators
- John N Jensen - Washington University in St. LouisMichael J Brenner - Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United StatesThomas H Tung - Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United StatesDaniel A Hunter - Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United StatesSusan E Mackinnon - Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States
- Resource Type
- Journal article
- Publication Details
- Annals of plastic surgery, Vol.54(4), pp.420-427
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/01.sap.0000151461.60911.c0
- PMID
- 15785285
- ISSN
- 0148-7043
- eISSN
- 1536-3708
- Number of pages
- 8
- Language
- English
- Date published
- 04/01/2005
- Academic Unit
- Surgery
- Record Identifier
- 9984701551402771
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