Journal article
Effect of Fenoterol on PAF-induced lung edema in isolated and perfused rabbit lungs
Respiration physiology, Vol.114(2), pp.153-160
1998
DOI: 10.1016/S0034-5687(98)00082-6
PMID: 9865589
Abstract
We have studied the effects of fenoterol on PAF-induced response in pulmonary circulation. We used 28 isolated and perfused rabbit lungs preparations: eight control preparations (CP), four vehicles preparations (VP), eight PAF preparations (PP) with two doses of PAF, one called low dose (LD=0.5 μg/kg of weight) and the other high dose (HD=1 μg/kg of weight) and eight Fenoterol preparations (FP) which we administered 0.05 mg of Fenoterol for 15 min, followed by a LD and HD of PAF. FP prevented elevation of pulmonary artery pressure (Ppa) as compared to PP, at LD of PAF: 12.615 (CI 95%: 8.57–20.885) versus 83.705 (CI 95%: 50.55–114.3) cm of water; and at HD of PAF: 19.38 (CI 95%: 11.235–28.94) versus 205.1 (CI 95%: 141.3–271) cm of water respectively. FP prevented the increase in fluid filtration rate (FFR) observed in PP at both doses of PAF LD: 0.765 (CI 95%: 0.07–3.385) versus −0.01 (CI 95%: −0.05–0.005) g/min; HD: 5.515 (CI 95%: 2.425–8.865) versus 0.03 (CI 95%: 0–0.33) g/min. Our results suggest that PAF has a vasoconstrictor effect that produces lung edema and this effect is inhibited by fenoterol.
Details
- Title: Subtitle
- Effect of Fenoterol on PAF-induced lung edema in isolated and perfused rabbit lungs
- Creators
- Liuska PesceSandra TristanoEliot FriedmanAlejandro ComellasHéctor MarcanoRoberto Sanchez de León
- Resource Type
- Journal article
- Publication Details
- Respiration physiology, Vol.114(2), pp.153-160
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0034-5687(98)00082-6
- PMID
- 9865589
- ISSN
- 0034-5687
- Language
- English
- Date published
- 1998
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Endocrinology and Diabetes; ICTS; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984093372002771
Metrics
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