Effect of GB virus C on response to antiretroviral therapy in HIV-infected Brazilians

I E Souza; W Zhang; R S Diaz; K Chaloner; D Klinzman; J T Stapleton

doi:10.1111/j.1468-1293.2005.00339.x

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Effect of GB virus C on response to antiretroviral therapy in HIV-infected Brazilians

Journal article

Open access

Peer reviewed

Effect of GB virus C on response to antiretroviral therapy in HIV-infected Brazilians

I E Souza, W Zhang, R S Diaz, K Chaloner, D Klinzman and J T Stapleton

HIV medicine, Vol.7(1), pp.25-31

01/2006

DOI: 10.1111/j.1468-1293.2005.00339.x

PMID: 16313289

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Abstract

GB virus C (GBV-C) infection is associated with delayed mortality in HIV-infected people in most, but not all, studies. Previous investigations of the effect of GBV-C viraemia on response to antiretroviral therapy (ART) were inconclusive. To determine the effect of GBV-C on ART, we retrospectively analysed plasma samples taken from patients in a prospective randomized clinical trial of ART in HIV-positive Brazilians. GBV-C viraemia was characterized by testing stored serum samples from 175 participants by reverse transcriptase-polymerase chain reaction (RT-PCR). Subjects were randomized to receive indinavir (n=59), zidovudine and lamivudine (n=58), or zidovudine, lamivudine and indinavir (n=58). The effect of GBV-C viraemia on the average change in HIV viral load and CD4 count following initiation of therapy was evaluated in a multiple regression analysis. The prevalence of GBV-C viraemia was similar to that observed in previous studies (24%). HIV viral load decreased following ART to a significantly greater extent in patients with GBV-C viraemia (by 0.48 log(10) HIV-1 RNA copies/mL, P=0.009, adjusting for age, ART group, and baseline CD4 count). Although there was no significant difference in change in CD4 count between individuals with and without GBV-C viraemia overall, CD4 counts were higher following 48 weeks of therapy in GBV-C viraemic individuals receiving the least potent ART regimen (zidovudine and lamivudine) compared with those without GBV-C infection. GBV-C viraemia is associated with an enhanced reduction of HIV viral load in response to ART. In this study of treatment-naive individuals during 48 weeks of follow up, patients with GBV-C viraemia had reductions in HIV viral load that were approximately 0.5 log copies/mL greater than those found in patients without GBV-C viraemia. This is similar to reductions observed with nucleoside reverse transcriptase inhibitors.

Flaviviridae Infections - complications

HIV Infections - virology

Humans

GB virus C

Male

RNA, Viral - blood

Treatment Outcome

CD4 Lymphocyte Count

Viral Load

HIV Infections - immunology

Viremia - complications

HIV-1 - isolation & purification

HIV Infections - complications

Adult

Anti-HIV Agents - therapeutic use

Female

HIV Infections - drug therapy

Retrospective Studies

Drug Therapy, Combination

Details

Title: Subtitle: Effect of GB virus C on response to antiretroviral therapy in HIV-infected Brazilians
Creators: I E Souza - Department of Internal Medicine, University of Iowa Roy, Iowa City, IA 52242, USA
W Zhang
R S Diaz
K Chaloner
D Klinzman
J T Stapleton
Resource Type: Journal article
Publication Details: HIV medicine, Vol.7(1), pp.25-31
DOI: 10.1111/j.1468-1293.2005.00339.x
PMID: 16313289
NLM abbreviation: HIV Med
ISSN: 1464-2662
eISSN: 1468-1293
Grant note: R01 AI058740 / NIAID NIH HHS
Language: English
Date published: 01/2006
Academic Unit: Microbiology and Immunology; Infectious Diseases; Internal Medicine
Record Identifier: 9984094611802771

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