Journal article
Effect of Glycocalyx-targeted Therapy on Vascular Function in Older Adults: A Randomized Controlled Trial
Journal of applied physiology (1985), Vol.136(6), pp.1488-1495
05/09/2024
DOI: 10.1152/japplphysiol.00150.2024
PMCID: PMC12461737
PMID: 38722754
Abstract
Advancing age increases cardiovascular disease risk, in part, because of impaired glycocalyx thickness and endothelial dysfunction. Glycocalyx-targeted therapies, such as Endocalyx Pro{trade mark, serif}, could improve both glycocalyx thickness and endothelial function in older adults, however, this has yet to be tested. We hypothesized that Endocalyx Pro{trade mark, serif} supplementation would increase glycocalyx thickness and endothelial function in older adults. Twenty-three older adults aged 66±7 years (52% female) were enrolled in a randomized, double-blind, placebo-controlled, parallel-arms study to investigate the effect of 12-week Endocalyx Pro{trade mark, serif} supplementation (3,712 mg/day) on glycocalyx thickness and endothelial function. Glycocalyx thickness was assessed using the GlycoCheck and endothelial function was determined via brachial artery flow-mediated dilation (FMD). Between-group comparisons revealed Endocalyx Pro{trade mark, serif} did not increase glycocalyx thickness in microvessels 4-25µm (P=0.33), 4-7µm (P=0.07), or 10-25µm (P=0.47) in diameter when compared with placebo. Additionally, Endocalyx Pro did not significantly improve FMD [mean ratio (95% CI) for between-group comparisons, 1.16 (0.77-1.74); P=0.48]. However, Endocalyx Pro{trade mark, serif} improved FMD normalized to shear rate area under the curve [mean ratio (95% CI) for between-group comparisons, 2.41 (1.14,4.13); P=0.001]. Moreover, Endocalyx Pro{trade mark, serif} increased capillary glycocalyx thickness more than placebo in individuals not taking anti-hypertensive medication [mean difference (95% CI) for between-group comparison, -0.08 (-0.15,-0.01); P=0.02]. Our pilot study suggests that Endocalyx Pro{trade mark, serif} supplementation is feasible in older adults but had no measurable effect on overall glycocalyx thickness and FMD. However, Endocalyx Pro{trade mark, serif} may have select effects on capillary glycocalyx thickness and FMD normalized to shear rate among older adults, but further investigation is warranted.
Details
- Title: Subtitle
- Effect of Glycocalyx-targeted Therapy on Vascular Function in Older Adults: A Randomized Controlled Trial
- Creators
- Colin J Gimblet - University of IowaJackson W Ernst - University of IowaBlair Bell - University of IowaKyle D Bos - Department of Health and Human Physiology, University of Iowa, Iowa City, IA, United StatesAmy K Stroud - University of IowaLinder H Wendt - University of IowaAnthony J Donato - University of UtahDiana I Jalal - University of IowaGary L Pierce - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.136(6), pp.1488-1495
- DOI
- 10.1152/japplphysiol.00150.2024
- PMID
- 38722754
- PMCID
- PMC12461737
- NLM abbreviation
- J Appl Physiol (1985)
- eISSN
- 1522-1601
- Grant note
- Russel B. Day and Florence D. Day Endowed Chair in Liberal Arts and Sciences fund at the University of Iowa 23PRE1012593 / American Heart Association (AHA)
- Language
- English
- Electronic publication date
- 05/09/2024
- Academic Unit
- Nephrology; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984626031502771
Metrics
20 Record Views