Journal article
Effect of Insulin and Dexamethasone on Fetal Assimilation of Maternal Glucose
Endocrinology (Philadelphia), Vol.152(1), pp.255-262
01/01/2011
DOI: 10.1210/en.2010-0959
PMCID: PMC3219051
PMID: 21084442
Abstract
Abstract The growing fetus depends upon transfer of glucose from maternal blood to fetal tissues. Insulin and glucocorticoid impact maternal glucose metabolism, but the effects of these hormones on fetal glucose assimilation in vivo are understudied. We thus used positron emission tomography imaging to determine the disposition of [18F]fluorodeoxyglucose (FDG) in rats on gestational d 20, quantifying the kinetic competition of maternal tissues and fetus for glucose. Three fasting maternal states were studied: after 2-d dexamethasone (DEX), during euglycemic hyperinsulinemic clamp insulin receiving (INS), and control (CON). In CON and DEX mothers, FDG accumulation in fetuses and placentae was substantial, rivaling that of maternal brain. By contrast, FDG accumulation was reduced in INS fetuses, placentae, and maternal brain by approximately 2-fold, despite no diminution in FDG extraction kinetics from maternal blood into these structures. The reduced FDG accumulation was due to more rapid clearance of FDG from the circulation in INS mothers, related to increased FDG avidity in INS select maternal tissues, including skeletal muscle, brown adipose tissue, and heart. DEX treatment of mothers reduced fetal weight by nearly 10%. Nonetheless, the accumulation of FDG into placentae and fetuses was similar in DEX and CON mothers. In our rat model, fetal growth restriction induced by DEX does not involve diminished glucose transport to the fetus. Maternal insulin action has little effect on the inherent avidity of the fetal-placental unit for glucose but increases glucose utilization by maternal tissues, thus indirectly reducing the glucose available to the fetus.
Details
- Title: Subtitle
- Effect of Insulin and Dexamethasone on Fetal Assimilation of Maternal Glucose
- Creators
- Andrew W Norris - Departments of Pediatrics (A.W.N., C.W., J.Y., A.B.S., S.H., J.L.S.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242Chunlin Wang - Departments of Pediatrics (A.W.N., C.W., J.Y., A.B.S., S.H., J.L.S.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242Jianrong Yao - Departments of Pediatrics (A.W.N., C.W., J.Y., A.B.S., S.H., J.L.S.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242Susan A Walsh - Small Animal Imaging Core (S.A.W., J.J.S., L.L.B.P.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242Alexander B Sawatzke - Departments of Pediatrics (A.W.N., C.W., J.Y., A.B.S., S.H., J.L.S.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242Shanming Hu - Departments of Pediatrics (A.W.N., C.W., J.Y., A.B.S., S.H., J.L.S.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242John J Sunderland - Radiology (J.J.S., L.L.B.P.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, Small Animal Imaging Core (S.A.W., J.J.S., L.L.B.P.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242Jeffrey L Segar - Departments of Pediatrics (A.W.N., C.W., J.Y., A.B.S., S.H., J.L.S.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242Laura L. B Ponto - Radiology (J.J.S., L.L.B.P.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, Small Animal Imaging Core (S.A.W., J.J.S., L.L.B.P.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Endocrinology (Philadelphia), Vol.152(1), pp.255-262
- DOI
- 10.1210/en.2010-0959
- PMID
- 21084442
- PMCID
- PMC3219051
- ISSN
- 0013-7227
- eISSN
- 1945-7170
- Language
- English
- Date published
- 01/01/2011
- Academic Unit
- Radiology; Endocrinology and Diabetes; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology; Biochemistry and Molecular Biology
- Record Identifier
- 9984047693902771
Metrics
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