Journal article
Effect of Lactobacillus rhamnosus HN001 on carriage of Staphylococcus aureus: results of the impact of probiotics for reducing infections in veterans (IMPROVE) study
BMC infectious diseases, Vol.18(1), pp.129-129
03/14/2018
DOI: 10.1186/s12879-018-3028-6
PMCID: PMC5853063
PMID: 29540160
Abstract
Background: Infection by Staphylococcus aureus (S. aureus) is a major cause of morbidity and mortality. Colonization by S. aureus increases the risk of infection. Little is known about decolonization strategies for S. aureus beyond antibiotics, however probiotics represent a promising alternative. A randomized controlled trial was conducted to determine the efficacy of Lactobacillus rhamnosus (L. rhamnosus) HN001 in reducing carriage of S. aureus at multiple body sites.
Methods: One hundred thirteen subjects, positive for S. aureus carriage, were recruited from the William S. Middleton Memorial Medical Center, Madison, WI, USA, and randomized by initial site of colonization, either gastrointestinal (GI) or extra-GI, to 4-weeks of oral L. rhamnosus HN001 probiotic, or placebo. Nasal, oropharyngeal, and axillary/groin swabs were obtained, and serial blood and fecal samples were collected. Differences in prevalence of S. aureus carriage at the end of the 4-weeks of treatment were assessed.
Results: The probiotic and placebo groups were similar in age, gender, and health history at baseline. S. aureus colonization within the stool samples of the extra-GI group was 15% lower in the probiotic than placebo group at the endpoint of the trial. Those in the probiotic group compared to the placebo group had 73% reduced odds (OR 0.27, 95% CI 0.07-0.98) of methicillin-susceptible S. aureus presence, and 83% reduced odds (OR 0.17, 95% CI 0.04-0.73) of any S. aureus presence in the stool sample at endpoint.
Conclusion: Use of daily oral L. rhamnosus HN001 reduced odds of carriage of S. aureus in the GI tract, however it did not eradicate S. aureus from other body sites.
Details
- Title: Subtitle
- Effect of Lactobacillus rhamnosus HN001 on carriage of Staphylococcus aureus: results of the impact of probiotics for reducing infections in veterans (IMPROVE) study
- Creators
- Shoshannah Eggers - University of Wisconsin–MadisonAnna K. Barker - University of Wisconsin–MadisonSusan Valentine - William S. Middleton Memorial Veterans HospitalTimothy Hess - University of Wisconsin–MadisonMegan Duster - University of Wisconsin–MadisonNasia Safdar - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- BMC infectious diseases, Vol.18(1), pp.129-129
- DOI
- 10.1186/s12879-018-3028-6
- PMID
- 29540160
- PMCID
- PMC5853063
- NLM abbreviation
- BMC Infect Dis
- ISSN
- 1471-2334
- eISSN
- 1471-2334
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- I01BX007080 / Biomedical Laboratory Research & Development Service of the VA Office of Research and Development UL1TR000427; TL1TR000429 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA TL1TR000429 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) T32GM008692 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 03/14/2018
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984446447902771
Metrics
9 Record Views