Effect of Lesions of the Anteroventral Third Ventricle (AV3V) on the Development of Hypertension in Spontaneously Hypertensive Rats

FRANK Gordon; JOSEPH Haywood; MICHAEL Brody; ALAN Johnson

doi:10.1161/01.HYP.4.3.387

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Effect of Lesions of the Anteroventral Third Ventricle (AV3V) on the Development of Hypertension in Spontaneously Hypertensive Rats

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Effect of Lesions of the Anteroventral Third Ventricle (AV3V) on the Development of Hypertension in Spontaneously Hypertensive Rats

FRANK Gordon, JOSEPH Haywood, MICHAEL Brody and ALAN Johnson

Hypertension (Dallas, Tex. 1979), Vol.4(3), pp.387-393

05/1982

DOI: 10.1161/01.HYP.4.3.387

PMID: 7068195

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Abstract

Lesions of the anteroventral third ventricle (AV3V), an angiotensin and osmosensitive region of the anterior hypothalamus, prevent or abort hypertension in a number of rat models. To determine if A V3V lesions alter hypertension in spontaneously hypertensive rats (SHR), lesions and control sham lesions were made in young SHR at 28 days of age. AV3V lesions had no effect on the development of hypertension in SHR. However, lesioned rats demonstrated significantly reduced pressor responses to intracerebroventricular injections of angiotensin II (AH) and hypertonic NaCl, and drinking produced by centrally administered AH. The depressor effect of central AH receptor blockade was also significantly attenuated in lesioned SHR. These effects appeared to be of central origin since the lesion did not affect the pressor action of intravenous AH or norepinephrine (NE). It is concluded that unlike other models of experimental hypertension (steroid-salt, oneand two-kidney renal, neurogenic) the development of hypertension in SHR does not depend upon the integrity of the AV3V region. (Hypertension 4387–393, 1982)

Details

Title: Subtitle: Effect of Lesions of the Anteroventral Third Ventricle (AV3V) on the Development of Hypertension in Spontaneously Hypertensive Rats
Creators: FRANK Gordon - From the Cardiovascular Center, Departments of Psychology and Pharmacology, The University of Iowa, Iowa City, Iowa
JOSEPH Haywood
MICHAEL Brody
ALAN Johnson
Resource Type: Journal article
Publication Details: Hypertension (Dallas, Tex. 1979), Vol.4(3), pp.387-393
DOI: 10.1161/01.HYP.4.3.387
PMID: 7068195
NLM abbreviation: Hypertension
ISSN: 0194-911X
eISSN: 1524-4563
Publisher: American Heart Association, Inc
Language: English
Date published: 05/1982
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213270402771

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