Journal article
Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys
PloS one, Vol.10(6), e0128138
2015
DOI: 10.1371/journal.pone.0128138
PMCID: PMC4457866
PMID: 26047515
Abstract
Five types of porous Nickel-Titanium (NiTi) alloy samples of different porosities and pore sizes were fabricated. According to compressive and fracture strengths, three groups of porous NiTi alloy samples underwent further cytocompatibility experiments. Porous NiTi alloys exhibited a lower Young's modulus (2.0 GPa ~ 0.8 GPa). Both compressive strength (108.8 MPa ~ 56.2 MPa) and fracture strength (64.6 MPa ~ 41.6 MPa) decreased gradually with increasing mean pore size (MPS). Cells grew and spread well on all porous NiTi alloy samples. Cells attached more strongly on control group and blank group than on all porous NiTi alloy samples (p < 0.05). Cell adhesion on porous NiTi alloys was correlated negatively to MPS (277.2 μm ~ 566.5 μm; p < 0.05). More cells proliferated on control group and blank group than on all porous NiTi alloy samples (p < 0.05). Cellular ALP activity on all porous NiTi alloy samples was higher than on control group and blank group (p < 0.05). The porous NiTi alloys with optimized pore size could be a potential orthopedic material.
Details
- Title: Subtitle
- Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys
- Creators
- Yu-Tao Jian - Sun Yat-sen UniversityYue Yang - Sun Yat-sen UniversityTian Tian - Sun Yat-sen UniversityClark Stanford - University of IowaXin-Ping Zhang - South China University of TechnologyKe Zhao - Sun Yat-sen University
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.10(6), e0128138
- DOI
- 10.1371/journal.pone.0128138
- PMID
- 26047515
- PMCID
- PMC4457866
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Language
- English
- Date published
- 2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Dentistry Administration; Prosthodontics; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center
- Record Identifier
- 9984367733402771
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