Journal article
Effect of Post-COVID-19 on Brain Volume and Glucose Metabolism: Influence of Time Since Infection and Fatigue Status
Brain sciences, Vol.13(4), 675
04/18/2023
DOI: 10.3390/brainsci13040675
PMCID: PMC10136956
PMID: 37190640
Abstract
Post-COVID-19 syndrome (PCS) fatigue is typically most severe <6 months post-infection. Combining magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging with the glucose analog [
18
F]-Fluorodeoxyglucose (FDG) provides a comprehensive overview of the effects of PCS on regional brain volumes and metabolism, respectively. The primary purpose of this exploratory study was to investigate differences in MRI/PET outcomes between people < 6 months (N = 18, 11 female) and > 6 months (N = 15, 6 female) after COVID-19. The secondary purpose was to assess if any differences in MRI/PET outcomes were associated with fatigue symptoms. Subjects > 6 months showed smaller volumes in the putamen, pallidum, and thalamus compared to subjects < 6 months. In subjects > 6 months, fatigued subjects had smaller volumes in frontal areas compared to non-fatigued subjects. Moreover, worse fatigue was associated with smaller volumes in several frontal areas in subjects > 6 months. The results revealed no brain metabolism differences between subjects > 6 and < 6 months. However, both groups exhibited both regional hypo- and hypermetabolism compared to a normative database. These results suggest that PCS may alter regional brain volumes but not metabolism in people > 6 months, particularly those experiencing fatigue symptoms.
Details
- Title: Subtitle
- Effect of Post-COVID-19 on Brain Volume and Glucose Metabolism: Influence of Time Since Infection and Fatigue Status
- Creators
- Justin R. Deters - University of IowaAlexandra C. Fietsam - University of IowaPhillip E. Gander - University of Iowa Hospitals and ClinicsLaura L. Boles PontoThorsten Rudroff - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Brain sciences, Vol.13(4), 675
- DOI
- 10.3390/brainsci13040675
- PMID
- 37190640
- PMCID
- PMC10136956
- NLM abbreviation
- Brain Sci
- eISSN
- 2076-3425
- Publisher
- MDPI
- Grant note
- 1S10OD025025-01 / University of Iowa
- Language
- English
- Date published
- 04/18/2023
- Academic Unit
- Neurology; Radiology; Neurosurgery; Otolaryngology; Health, Sport, and Human Physiology
- Record Identifier
- 9984399501102771
Metrics
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