Journal article
Effect of Resveratrol on Endothelial Function in Patients with CKD and Diabetes: A Randomized Controlled Trial
Clinical journal of the American Society of Nephrology, Vol.19(2), pp.161-168
02/2024
DOI: 10.2215/CJN.0000000000000337
PMCID: PMC10861109
PMID: 37843843
Abstract
Background: Patients with chronic kidney disease (CKD) and diabetes are at higher risk of developing cardiovascular disease, in part, because of impaired endothelial function. Cardioprotective compounds such as resveratrol could improve endothelial function and attenuate the cardiovascular burden in patients with CKD and diabetes. We hypothesized that resveratrol supplementation would improve endothelial function in patients with CKD and diabetes. Methods: 28 adults aged 68±7 years (84% men) with stage 3 CKD and diabetes were enrolled in a randomized, double-blind, placebo-controlled, crossover study to investigate the effects of 6-week resveratrol supplementation (400 mg/day) on endothelial function. Endothelial function was determined via brachial artery flow-mediated dilation. Results: Mean values for estimated glomerular filtration rate (eGFR)and HbA 1c were 40±9 ml/min/1.73m 2 and 7.36±0.72%, respectively. Compared to placebo, resveratrol supplementation increased flow-mediated dilation (ratio of geometric mean changes and 95% C.I. for between group comparisons= 1.43 (1.15,1.77); p value= 0.001). eGFR, HbA 1c , blood pressure, and nitroglycerin-mediated dilation were unchanged with resveratrol or placebo (P= 0.15), suggesting the observed change in flow-mediated dilation was likely independent of changes in traditional cardiovascular risk factors. Conclusions: Resveratrol supplementation improved endothelial function in patients with CKD and diabetes.
Details
- Title: Subtitle
- Effect of Resveratrol on Endothelial Function in Patients with CKD and Diabetes: A Randomized Controlled Trial
- Creators
- Colin J. Gimblet - University of IowaNicholas T. Kruse - Central Michigan UniversityKatharine Geasland - University of IowaJeni Michelson - Division of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USAMingyao Sun - University of IowaSafur Rehman Mandukhail - University of IowaLinder H. Wendt - University of IowaPatrick Ten Eyck - University of IowaGary L. Pierce - University of IowaDiana I. Jalal - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical journal of the American Society of Nephrology, Vol.19(2), pp.161-168
- DOI
- 10.2215/CJN.0000000000000337
- PMID
- 37843843
- PMCID
- PMC10861109
- NLM abbreviation
- Clin J Am Soc Nephrol
- ISSN
- 1555-9041
- eISSN
- 1555-905X
- Grant note
- DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: R01HL134738; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: DK007690; DOI: 10.13039/100000968, name: American Heart Association, award: 23PRE1012593; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: DK007690; DOI: 10.13039/100000002, name: National Institutes of Health, award: UM1TR004403; DOI: 10.13039/100000002, name: National Institutes of Health, award: UM1TR004403; name: Russell B. Day and Florence D. Day Endowed Chair in Liberal Arts and Sciences fund
- Language
- English
- Electronic publication date
- 10/16/2023
- Date published
- 02/2024
- Academic Unit
- Clinical Research Unit; Biostatistics; Nephrology; Health, Sport, and Human Physiology ; Internal Medicine; Design Biostat and Ethics
- Record Identifier
- 9984480137002771
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