Journal article
Effect of Rosiglitazone on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease
Circulation (New York, N.Y.), Vol.121(10), pp.1176-1187
03/16/2010
DOI: 10.1161/CIRCULATIONAHA.109.881003
PMID: 20194881
Abstract
Background-Rosiglitazone has several properties that may affect progression of atherosclerosis. The Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in Diabetes Patients With Cardiovascular History (APPROACH) study was undertaken to determine the effect of the thiazolidinedione rosiglitazone on coronary atherosclerosis as assessed by intravascular ultrasound compared with the sulfonylurea glipizide.
Methods and Results-This was a randomized, double-blind, controlled 18-month study in 672 patients aged 30 to 80 years with established type 2 diabetes mellitus treated by lifestyle, 1 oral agent, or submaximal doses of 2 oral agents who had at least 1 atherosclerotic plaque with 10% to 50% luminal narrowing in a coronary artery that had not undergone intervention during a clinically indicated coronary angiography or percutaneous coronary intervention. The primary outcome was change in percent atheroma volume in the longest and least angulated epicardial coronary artery that had not undergone intervention. Secondary outcomes included change in normalized total atheroma volume and change in total atheroma volume in the most diseased baseline 10-mm segment. Rosiglitazone did not significantly reduce the primary outcome of percent atheroma volume compared with glipizide (-0.64%; 95% confidence interval, -1.46 to 0.17; P=0.12). The secondary outcome of normalized total atheroma volume was significantly reduced by rosiglitazone compared with glipizide (-5.1 mm(3); 95% confidence interval, -10.0 to -0.3; P=0.04); however, no significant difference between groups was observed for the change in total atheroma volume within the most diseased baseline 10-mm segment (-1.7 mm(3); 95% confidence interval, -3.9 to 0.5; P=0.13).
Conclusions-Rosiglitazone did not significantly decrease the primary end point of progression of coronary atherosclerosis more than glipizide in patients with type 2 diabetes mellitus and coronary atherosclerosis.
Details
- Title: Subtitle
- Effect of Rosiglitazone on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease
- Creators
- Hertzel C. Gerstein - McMaster UniversityRobert E. RatnerChristopher P. Cannon - Brigham and Women's HospitalPatrick W. Serruys - Erasmus University RotterdamHector M. Garcia-Garcia - Erasmus University RotterdamGerrit-Anne van Es - Erasmus University RotterdamNikheel S. KolatkarBarbara G. KravitzDiane M. MillerChun HuangPeter J. Fitzgerald - Stanford UniversityRichard W. Nesto - Lahey Hospital and Medical CenterAPPROACH Study Group
- Contributors
- Scott Eberly (Contributor) - University of Iowa, Family and Community Medicine
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.121(10), pp.1176-1187
- DOI
- 10.1161/CIRCULATIONAHA.109.881003
- PMID
- 20194881
- NLM abbreviation
- Circulation
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 12
- Grant note
- GlaxoSmithKline
- Language
- English
- Date published
- 03/16/2010
- Academic Unit
- Family and Community Medicine
- Record Identifier
- 9984297338402771
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