Journal article
Effect of Salvia miltiorrhiza Hydrophilic Extract on the Endothelial Biomarkers in Diabetic Patients with Chronic Artery Disease
Phytotherapy research, Vol.26(10), pp.1575-1578
10/2012
DOI: 10.1002/ptr.4611
PMID: 22318996
Abstract
The aim of this pilot study was to investigate whether the administration of Salvia miltiorrhiza hydrophilic extract (SMHE) reduced the level of soluble vascular cell adhesion molecule-1 (sVCAM-1) and von Willebrand factor (vWF) in diabetic patients with coronary heart disease (CHD). Sixty-two diabetic patients with CHD were recruited and randomly assigned into placebo and treatment groups. Patients were given SMHE for 60 days. Levels of sVCAM-1, vWF and oxidative low density lipoprotein (oxLDL) were determined by using enzyme linked immunosorbent assay (ELISA). The results showed that the levels of VCAM-1 and vWF positively correlated with the level of oxLDL in diabetic patients with CHD. Levels of sVCAM-1 and vWF in serum were reduced significantly in patients receiving SMHE treatment at day 60 in comparison with the baseline. Administration of SMHE also led to a clear decrease in the levels of oxLDL in diabetic patients with CHD. In summary, this study suggests that SMHE has a potential protective effect on the development of diabetic cardiovascular disease. Copyright (c) 2012 John Wiley & Sons, Ltd.
Details
- Title: Subtitle
- Effect of Salvia miltiorrhiza Hydrophilic Extract on the Endothelial Biomarkers in Diabetic Patients with Chronic Artery Disease
- Creators
- Shuhong Qian - Zhengzhou UniversityShijin Wang - Zhengzhou UniversityPing Fan - Zhengzhou People's HospitalDongxia Huo - Zhengzhou UniversityLiping Dai - Zhengzhou UniversityQingwen Qian - Zhengzhou University
- Resource Type
- Journal article
- Publication Details
- Phytotherapy research, Vol.26(10), pp.1575-1578
- Publisher
- Wiley
- DOI
- 10.1002/ptr.4611
- PMID
- 22318996
- ISSN
- 0951-418X
- eISSN
- 1099-1573
- Number of pages
- 4
- Grant note
- 0511050500 / Nature Science Foundation of Henan province, China
- Language
- English
- Date published
- 10/2012
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984420941802771
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