Effect of Segmental Bronchoalveolar Lavage on Quantitative Computed Tomography of the Lung

Luke M Gabe; Kimberly M Baker; Edwin J.R van Beek; Gary W Hunninghake; Joseph M Reinhardt; Eric A Hoffman

doi:10.1016/j.acra.2011.03.006

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Effect of Segmental Bronchoalveolar Lavage on Quantitative Computed Tomography of the Lung

Journal article

Peer reviewed

Effect of Segmental Bronchoalveolar Lavage on Quantitative Computed Tomography of the Lung

Luke M Gabe, Kimberly M Baker, Edwin J.R van Beek, Gary W Hunninghake, Joseph M Reinhardt and Eric A Hoffman

Academic radiology, Vol.18(7), pp.876-884

2011

DOI: 10.1016/j.acra.2011.03.006

PMCID: PMC3115559

PMID: 21669353

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https://www.research.ed.ac.uk/en/publications/84b6fb8f-b023-43b8-bf7a-9c82f832bd69View

Open Access

Abstract

With employment of both multidetector computed tomography (MDCT) and endobronchial procedures in multicenter studies, effects of timing of endobronchial procedures on quantitative imaging (Q-MDCT) metrics is a question of increasing importance. Six subjects were studied via MDCT at baseline, immediately following and at 4 hours and 24 hours post-bronchoalveolar lavage (BAL) (right middle lobe and lingula). Through quantitative image analysis, non-air, or “tissue” volume (TV) in each lung and lobe was recorded. Change in TV from baseline was used to infer retention and redistribution of lavage fluid. Bronchoscopist reported unrecovered BAL volume correlated well with Q-MDCT for whole lung measures, but less well with individual lobes indicating redistribution. TV in all lobes except the right lower lobe differed significantly ( P < .05) from baseline immediately post lavage. At 24 hours, all lobes except the left lower lobe (small 1% mean difference at 24 hours) returned to baseline. These findings suggest fluid movement affecting Q-MDCT metrics between lobes and between lungs before eventual resolution, and preclude protocols involving the lavage of one lung and imaging of the other to avoid interactions. We demonstrate that Q-MDCT is sensitive to lavage fluid retention and redistribution, and endobronchial procedures should not precede Q-MDCT imaging by less than 24 hours.

Bronchoscopy

lavage

lung fluid

multicenter trials

quantitative computed tomography

Details

Title: Subtitle: Effect of Segmental Bronchoalveolar Lavage on Quantitative Computed Tomography of the Lung
Creators: Luke M Gabe - University of Iowa
Kimberly M Baker - University of Iowa
Edwin J.R van Beek - University of Iowa
Gary W Hunninghake - University of Iowa
Joseph M Reinhardt - University of Iowa
Eric A Hoffman - University of Iowa
Resource Type: Journal article
Publication Details: Academic radiology, Vol.18(7), pp.876-884
DOI: 10.1016/j.acra.2011.03.006
PMID: 21669353
PMCID: PMC3115559
NLM abbreviation: Acad Radiol
ISSN: 1076-6332
eISSN: 1878-4046
Publisher: Elsevier Inc
Grant note: HL-064368; NIH HL-RO1-079406 / National Institutes of Health
Language: English
Date published: 2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984197147702771

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