Journal article
Effect of Shear Force on Intervertebral Disc (IVD) Degeneration: An In Vivo Rat Study
Annals of biomedical engineering, Vol.40(9), pp.1996-2004
09/2012
DOI: 10.1007/s10439-012-0570-z
PMID: 22527013
Abstract
Mechanical stress on the intervertebral disc (IVD) may contribute significantly to IVD degeneration, although its pathomechanism has not been fully understood. The purpose of this study was to test the hypothesis that sustained application of static shear force would result in IVD degeneration with minimum injury. We applied shear force on the rat lumbar spine (L5–L6) using a custom-designed loading device for 1 or 2 weeks. Degenerative changes such as nucleus pulposus cavity loss and border disruption were observed from the histology sections, indicating that the application of sustained dorsoventral shear force on the L6 vertebra induced degeneration of the IVDs in L5–L6 and adjacent levels of motion segment in 1 and 2 weeks. The findings of the present study could be useful for gaining a more relevant understanding of the biomechanical load factors of IVD degeneration not only for enabling better therapeutic interventions but also reducing the risk of low back injury.
Details
- Title: Subtitle
- Effect of Shear Force on Intervertebral Disc (IVD) Degeneration: An In Vivo Rat Study
- Creators
- Jaehyun Kim - Wake Forest University Winston Salem NC 27157 USASeok-Jo Yang - Department of Mechatronics Engineering Chungnam National University Daejeon KoreaHyunchul Kim - Department of Bioengineering University of Maryland College Park MD 20742 USAYoonsang Kim - Division of Epidemiology and Biostatistics University of Illinois at Chicago Chicago IL 60612 USAJoon Park - Department of Biomedical Engineering University of Iowa 1402 Seamans Center Iowa City IA 52242 USACandis DuBose - Department of Biomedical Engineering University of Iowa 1402 Seamans Center Iowa City IA 52242 USATae-Hong Lim - Department of Biomedical Engineering University of Iowa 1402 Seamans Center Iowa City IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Annals of biomedical engineering, Vol.40(9), pp.1996-2004
- Publisher
- Springer US; Boston
- DOI
- 10.1007/s10439-012-0570-z
- PMID
- 22527013
- ISSN
- 0090-6964
- eISSN
- 1573-9686
- Language
- English
- Date published
- 09/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984064591902771
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