Journal article
Effect of Stimulation of Carotid Chemoreceptors on Total and Regional Cerebral Blood Flow
Circulation research, Vol.38(1), pp.20-25
01/1976
DOI: 10.1161/01.RES.38.1.20
PMID: 942578
Abstract
This study was performed to determine whether stimulation of the carotid chemoreceptors increases total or regional cerebral blood flow and whether activation of arterial chemoreceptors contributes to cerebral vasodilation during systemic hypoxemia. In anesthetized and ventilated dogs, carotid chemoreceptors were stimulated with nicotine or hypoxic and hypercapnic blood. To measure total and regional cerebral blood flow, we used labeled 15-μ microspheres. Stimulation of chemoreceptors did not increase cerebral blood flow or produce significant redistribution of cerebral blood flow, even though the chemoreflex was intact in these animals (as manifested by vasoconstriction in muscle, kidney, and small bowel) and the cerebral vessels dilated in response to systemic hypercapnia. In other studies in anesthetized, ventilated dogs and rhesus monkeys, cerebral vasodilator responses to systemic hypoxemia were observed before and after denervation of carotid and aortic chemoreceptors. Systemic hypoxemia produced large and equivalent increases in cerebral blood flow before and after chemodenervation. We conclude that stimulation of carotid chemoreceptors does not produce cerebral vasodilation and that chemoreceptors do not contribute significantly to cerebral vasodilation during systemic hypoxemia.
Details
- Title: Subtitle
- Effect of Stimulation of Carotid Chemoreceptors on Total and Regional Cerebral Blood Flow
- Creators
- DONALD HEISTAD - Cardiovascular Division, Department of Internal Medicine, the Cardiovascular Center, and the Department of Radiology, University of Iowa College of Medicine, Iowa City, IowaMELVIN MARCUSJAMES EHRHARDTFRANCOIS ABBOUD
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.38(1), pp.20-25
- DOI
- 10.1161/01.RES.38.1.20
- PMID
- 942578
- NLM abbreviation
- Circ Res
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 01/1976
- Academic Unit
- Radiology; Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025698302771
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